Natriuretic peptides in the treatment of heart failure

Journal of Cardiac Failure
H Yasue, M Yoshimura

Abstract

This study was designed to examine the hemodynamic, renal, and hormonal effects of infusion of A-type natriuretic peptide (ANP) and B-type natriuretic peptide (BNP) in patients with congestive heart failure (CHF). We infused synthetic human ANP or BNP at a rate of 0.1 microgram/kg/ min in patients with CHF and control subjects. ANP and BNP infusion decreased pulmonary capillary wedge pressure (ANP: from 24 +/- 1 to 12 +/- 2 mmHg; BNP: from 21 +/- 3 to 14 +/- 4 mmHg, P < .01, respectively) and systemic vascular resistance (ANP: from 2,129 +/- 293 to 1,737 +/- 293 dyne.sec.cm-5; BNP: from 2,485 +/- 379 to 1,771 +/- 195 dyne.sec.cm-5, P < .01, respectively), and increased stroke volume index (ANP: from 26 +/- 4 to 32 +/- 4 mL/m2; BNP: from 26 +/- 4 to 32 +/- 4 mL/m2, P < .01, respectively) in patients with CHF. ANP and BNP infusion increased urine volume (ANP: from 0.7 +/- 0.3 to 4.5 +/- 3.3 mL/min, BNP; 0.8 +/- 0.2 to 5.3 +/- 1.0 mL/min, P < .01, respectively). excretion of sodium (ANP: from 53 +/- 26 to 478 +/- 389 microEq/min, P = NS; BNP: from 77 +/- 21 to 754 +/- 108 microEq/min, P < .01) and chloride (ANP: from 61 +/- 31 to 470 +/- 369 microEq/min, P = NS, BNP; from 74 +/- 20 to 709 +/- 103 microEq/min, P < .01) in patients ...Continue Reading

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Citations

Aug 16, 2008·Pediatric Cardiology·Sarina K BeheraJuan C Alejos
Oct 28, 2009·Journal of Cardiovascular Pharmacology·Isaac GeorgeJie Wang
Sep 27, 2005·The Heart Surgery Forum·Nader Moazami, Mehmet C Oz
Apr 13, 2011·International Heart Journal·Tomohiro MizutaniTohru Izumi
Aug 12, 2014·Regulatory Peptides·Song GuoMessoud Ashina
Jul 11, 2006·Pediatric Cardiology·J L JefferiesJ A Towbin
Sep 11, 2007·Journal of Cardiac Failure·John L JefferiesJeffrey A Towbin
Nov 24, 1999·The Journal of Laboratory and Clinical Medicine·N ValliL Bordenave
Jun 27, 2002·Expert Opinion on Pharmacotherapy·Sheila A Doggrell, Lindsay Brown
Feb 13, 2007·Journal of the American College of Cardiology·Robert M MentzerUNKNOWN NAPA Investigators
May 8, 2010·Journal of the American College of Cardiology·Christopher D SteadmanGerry P McCann
Jan 4, 2003·Hypertension·Kim van der ZanderPeter W de Leeuw
Mar 15, 2008·Critical Pathways in Cardiology·Mandeep R Mehra, Alan Maisel
Feb 1, 2005·Expert Review of Pharmacoeconomics & Outcomes Research·Claire B HunterDaniel E Hilleman
Jul 14, 2005·Fundamental & Clinical Pharmacology·Alphons J H M HoubenPeter W de Leeuw
May 8, 2009·Expert Review of Cardiovascular Therapy·Michiko ShimadaThomas M Beaver
Jul 25, 2019·International Journal of Molecular Sciences·Ryuji OkamotoMasaaki Ito

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