Natto mucilage containing poly-gamma-glutamic acid increases soluble calcium in the rat small intestine

Bioscience, Biotechnology, and Biochemistry
H TanimotoT Noguchi

Abstract

We prepared natto (fermented soybeans) mucilage containing poly-gamma-glutamic acid (gamma-PGA) from commercial natto. The effect of natto mucilage on calcium (Ca) solubility in vitro and in vivo was investigated. Ca solubility in vitro increased with an increase in the amount of natto mucilage, due to inhibition of the formation of an insoluble complex of Ca with phosphate by natto mucilage. Rats were fed with 5 g of soybean protein isolate, natto, mucilage-free natto, or natto mucilage diet for 1.5 h. Small intestinal contents were collected 2.5 h after ingestion. In the lower half of the small intestine, both the amount and the percentage of soluble Ca of intestinal contents were significantly higher (P < 0.001) in rats fed with natto mucilage diet than in those fed with the other diets. Natto mucilage also increased Ca solubility in vivo. These results suggested that gamma-PGA is responsible for the increasing effect of natto mucilage on Ca solubility.

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Citations

Aug 9, 2013·Bioscience, Biotechnology, and Biochemistry·Eun-Hei LeeBae-Hwan Kim
Dec 9, 2008·Bioscience, Biotechnology, and Biochemistry·Li-Chan YangWen-Chuan Lin
Oct 4, 2012·Animal : an International Journal of Animal Bioscience·P SunL F Deng
Oct 27, 2015·International Journal of Molecular Sciences·Makoto AshiuchiKeizo Yoneda
Jul 17, 2013·Microbial Biotechnology·Makoto Ashiuchi
Feb 12, 2015·Journal of Pharmaceutical and Biomedical Analysis·Makoto AshiuchiTaisuke Wakamatsu
Oct 8, 2014·Microbiology·Adetoro OgunleyeIza Radecka
Oct 11, 2016·Journal of Environmental Radioactivity·Shigeki Sakamoto, Yoshinori Kawase
Jan 12, 2008·Journal of the American College of Nutrition·Hiroyuki TanimotoSusan J Fairweather-Tait
Jan 13, 2017·Environmental Science and Pollution Research International·Zhengfei GuoLijun Gan
Jun 12, 2009·Critical Reviews in Microbiology·Charles ParkoudaMogens Jakobsen
Mar 1, 2019·Food Science and Biotechnology·Pov Ratha, Deok-Young Jhon
Jan 9, 2009·Journal of Agricultural and Food Chemistry·F Y SiaoB H Chen
Jun 3, 2021·International Journal of Molecular Sciences·Il-Sup KimCheorl-Ho Kim
Jul 13, 2021·Critical Reviews in Food Science and Nutrition·Danjun GuoTao Hou
Dec 23, 2004·Journal of Agricultural and Food Chemistry·Yukako YamagishiKoji Takahashi

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