Natural and molecular history of prolactinoma: insights from a Prlr-/- mouse model

Oncotarget
Valérie BernardNadine Binart

Abstract

Lactotroph adenoma, also called prolactinoma, is the most common pituitary tumor but little is known about its pathogenesis. Mouse models of prolactinoma can be useful to better understand molecular mechanisms involved in abnormal lactotroph cell proliferation and secretion. We have previously developed a prolactin receptor deficient (Prlr -/- ) mouse, which develops prolactinoma. The present study aims to explore the natural history of prolactinoma formation in Prlr -/- mice, using hormonal, radiological, histological and molecular analyses to uncover mechanisms involved in lactotroph adenoma development. Prlr -/- females develop large secreting prolactinomas from 12 months of age, with a penetrance of 100%, mimicking human aggressive densely granulated macroprolactinoma, which is a highly secreting subtype. Mean blood PRL measurements reach 14 902 ng/mL at 24 months in Prlr -/- females while PRL levels were below 15 ng/mL in control mice (p < 0.01). By comparing pituitary microarray data of Prlr -/- mice and an estrogen-induced prolactinoma model in ACI rats, we pinpointed 218 concordantly differentially expressed (DE) genes involved in cell cycle, mitosis, cell adhesion molecules, dopaminergic synapse and estrogen signa...Continue Reading

References

Jan 1, 1977·Journal of Neural Transmission·D C EikenburgK E Moore
Jun 1, 1997·Molecular Endocrinology·K M ScullyM G Rosenfeld
Sep 16, 1998·Proceedings of the National Academy of Sciences of the United States of America·M DelcommenneS Dedhar
Jun 12, 1999·Developmental Biology·C BriskenC J Ormandy
Apr 20, 2001·Proceedings of the National Academy of Sciences of the United States of America·V G TusherG Chu
Feb 5, 2002·Annual Review of Physiology·Vincent GoffinPaul A Kelly
Dec 14, 2002·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Zhi Rong QianToshiaki Sano
Jan 29, 2003·Proceedings of the National Academy of Sciences of the United States of America·Marcelo Paez-PeredaEduardo Arzt
Jan 18, 2006·Pituitary·Mark E Molitch
May 18, 2006·Endocrine Reviews·Mary P GillamAnnamaria Colao
May 27, 2006·Science·Outi VierimaaLauri A Aaltonen
Sep 14, 2006·The Journal of Clinical Endocrinology and Metabolism·Adrian F DalyAlbert Beckers
Feb 17, 2007·Clinical Endocrinology·Iain EwingAshley B Grossman
Jul 8, 2008·Journal of Neuroendocrinology·D R Grattan, I C Kokay
Aug 5, 2008·Cancer Research·George VlotidesShlomo Melmed
Mar 12, 2010·Journal of Molecular Endocrinology·Monica Fedele, Alfredo Fusco
Jun 11, 2010·The Journal of Clinical Endocrinology and Metabolism·Antti RaappanaTapio Pirilä
Oct 8, 2011·Molecular Endocrinology·Yunguang TongShlomo Melmed
Jun 12, 2012·Journal of Cell Communication and Signaling·Aneesha RadhakrishnanAditi Chatterjee
Nov 8, 2013·The New England Journal of Medicine·Paul J NeweyRajesh V Thakker
Jan 15, 2014·Nature Genetics·Priscilla K BrastianosSandro Santagata
Dec 17, 2014·International Journal of Endocrinology·Carolina CristinaDamasia Becu-Villalobos
May 5, 2016·Nucleic Acids Research·Maxim V KuleshovAvi Ma'ayan
Nov 2, 2016·Endocrinology·Jyoti KapaliBuffy S Ellsworth
Feb 9, 2017·JAMA : the Journal of the American Medical Association·Mark E Molitch

❮ Previous
Next ❯

Citations

May 3, 2019·Current Opinion in Obstetrics & Gynecology·Sydney Chang, Alan B Copperman
Mar 24, 2020·Endocrine Reviews·Vinaya Srirangam Nadhamuni, Márta Korbonits
Mar 23, 2019·Nature Reviews. Endocrinology·Valérie BernardNadine Binart

❮ Previous
Next ❯

Methods Mentioned

BETA
dissecting

Software Mentioned

GEO2R
Genespring
Radiant Dicom viewer
GeneMania
Significance Analysis of Microarrays
Enrichr
Cytoscape

Related Concepts

Related Feeds

Adhesion Molecules in Health and Disease

Cell adhesion molecules are a subset of cell adhesion proteins located on the cell surface involved in binding with other cells or with the extracellular matrix in the process called cell adhesion. In essence, cell adhesion molecules help cells stick to each other and to their surroundings. Cell adhesion is a crucial component in maintaining tissue structure and function. Discover the latest research on adhesion molecule and their role in health and disease here.

AKT Pathway

This feed focuses on the AKT serine/threonine kinase, which is an important signaling pathway involved in processes such as glucose metabolism and cell survival.

© 2022 Meta ULC. All rights reserved