Natural and synthetic compound anti-Trichomonas vaginalis: an update review

Parasitology Research
Patrícia de Brum VieiraTiana Tasca

Abstract

Trichomonas vaginalis is a flagellate protozoan that causes trichomonosis, a sexually transmitted disease of worldwide importance. However, the infection has long received much less attention than other parasitic and sexually transmitted diseases. This negligence leads to poor diagnosis and underestimated prevalence values, and consequently, it has been associated to increasing acquisition and transmission of HIV, pregnancy outcomes, infertility, pelvic inflammatory disease, and cervical and prostate cancer. In view of increased resistance to drugs belonging to the nitroimidazole class, new treatment alternatives are urgently needed. Natural products provide an immeasurable wealth of active molecules, and a great number of new drugs have been originated from these compounds. In addition, new synthetic products or derivatives from old drugs also provide an alternative to treat trichomonosis. Albeit many studies have been performed with natural products against T. vaginalis, none of them progressed to clinical trials. Overall, inadequate financial investments are made, and no alternative treatment for trichomonosis has been discovered; meanwhile, hundreds of thousands of people will remain infected and suffering the serious conse...Continue Reading

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Related Concepts

Antitrichomonal Agents
Azoles
Biological Products
Drug Resistance
Trichomonas Infections
Trichomonas vaginalis
Aquatic Organisms
Analogs & derivatives
Uterine Cervicitis
Clinical Trials

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