Natural and synthetic compound anti-Trichomonas vaginalis: an update review

Parasitology Research
Patrícia de Brum VieiraTiana Tasca

Abstract

Trichomonas vaginalis is a flagellate protozoan that causes trichomonosis, a sexually transmitted disease of worldwide importance. However, the infection has long received much less attention than other parasitic and sexually transmitted diseases. This negligence leads to poor diagnosis and underestimated prevalence values, and consequently, it has been associated to increasing acquisition and transmission of HIV, pregnancy outcomes, infertility, pelvic inflammatory disease, and cervical and prostate cancer. In view of increased resistance to drugs belonging to the nitroimidazole class, new treatment alternatives are urgently needed. Natural products provide an immeasurable wealth of active molecules, and a great number of new drugs have been originated from these compounds. In addition, new synthetic products or derivatives from old drugs also provide an alternative to treat trichomonosis. Albeit many studies have been performed with natural products against T. vaginalis, none of them progressed to clinical trials. Overall, inadequate financial investments are made, and no alternative treatment for trichomonosis has been discovered; meanwhile, hundreds of thousands of people will remain infected and suffering the serious conse...Continue Reading

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Citations

Nov 26, 2015·Bioorganic & Medicinal Chemistry Letters·Sierra BeckBrian J Stockman
Mar 30, 2016·Bioorganic & Medicinal Chemistry Letters·Patrícia de Brum VieiraTiana Tasca
Aug 6, 2015·BMC Infectious Diseases·Patricia Kissinger
Oct 30, 2016·Biomedical Journal·Camila Braz Menezes, Tiana Tasca
Sep 30, 2016·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Dariana Pimentel Gomes HübnerTiana Tasca
Oct 31, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Seong-Min LeeDongyun Shin
Mar 25, 2018·Parasitology Research·Fernanda Gobbi BitencourtTiana Tasca
Dec 20, 2019·Parasitology Research·Raquel Nascimento das NevesSibele Borsuk
Nov 19, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Natalia MalloJosé Manuel Leiro
Feb 19, 2021·International Journal for Parasitology. Drugs and Drug Resistance·Alexander Y F LamSamantha J Emery-Corbin

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