Natural and synthetic coumarins as antileishmanial agents: A review.

European Journal of Medicinal Chemistry
Guilherme Arraché GonçalvesVeraLucia Eifler-Lima

Abstract

The neglected tropical disease leishmaniasis is still a major public health problem that affects millions of people worldwide. Related to poor-living conditions, this vector-borne disease presents multiple clinical manifestations - from asymptomatic to systemic conditions. The protozoans of the genus Leishmania are the etiologic agents transmitted through the bite of sandflies, the main vectors. Current pharmacological interventions are outdated and present several drawbacks, thus the search for new antileishmanial compounds is imperative. Medicinal chemists have been continuously investigating for new alternatives to combat leishmaniasis, and coumarins play a pivotal role in this search. Various biological properties have been described owing to coumarin's structural versatility combined with its unique features, including antileishmanial activity. The aim of this review is to highlight the most relevant studies between 1997 and 2020 and provide a guide for the development of new antileishmanial coumarins. Naturally occurring and synthetically designed coumarins are comprised in this review, along with a structure-activity relationship to provide an insight for further development of coumarins with antileishmanial activity.

Citations

Jan 23, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Aitor CarneiroLourdes Santana
Mar 23, 2021·Phytochemistry Reviews : Proceedings of the Phytochemical Society of Europe·Guilherme Arraché GonçalvesGilsane Lino von Poser
Apr 4, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Mziyanda MbabaSetshaba D Khanye
Aug 4, 2021·Organic & Biomolecular Chemistry·Yan-Shan ChenHua Yang
Aug 14, 2021·Beilstein Journal of Organic Chemistry·Natália Menezes MoreiraArlene Gonçalves Corrêa
Oct 9, 2021·Natural Product Reports·Senhua ChenZhigang She

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