PMID: 9637345Jun 24, 1998Paper

Natural and synthetic thymic peptides as therapeutics for immune dysfunction

International Journal of Immunopharmacology
V G Morozov, V Kh Khavinson

Abstract

Natural thymic peptides have been isolated from calf thymus by mild acid extraction. Pharmaceutical containing natural peptides (Thymalin) was put into practice as immunocorrector. One of the immunomodulatory molecules (L-Glu-L-Trp) has been isolated from Thymalin by reversed-phase high performance liquid chromatography. Pharmaceutical containing this agent (Thymogen) was designed on the base of synthesized dipeptide. A novel immunomodulatory dipeptide was synthesized and termed Vilon. Both natural and synthetic pharmaceuticals activated T-cell differentiation, T-cell recognition of peptide-MHC complexes, induced the changes in intracellular composition of cyclic nucleotides and cytokine [interleukin (IL-2), interferon (IFN)] excretion of blood lymphocytes. Synthetic dipeptides activated neutrophil chemotaxis and phagocytosis. They had no influence on antioxidant response in thymocytes in comparison with natural peptides. Thymalin and Thymogen were used in persons with chronic pathology and immune dysfunction. The results indicate that thymic peptides participate in the regulating mechanisms of inflammatory processes as cytokine antagonists and show the difference between natural and synthetic products. It is important for the ...Continue Reading

References

Feb 1, 1977·Proceedings of the National Academy of Sciences of the United States of America·A L GoldsteinJ Meienhofer
Nov 21, 1992·Annals of the New York Academy of Sciences·E Bergamini
Jan 1, 1991·International Journal of Immunopharmacology·J W HaddenE M Hadden
Jan 1, 1985·Springer Seminars in Immunopathology·S Specter, J W Hadden
Sep 1, 1982·The Journal of Clinical Investigation·R M SeniorR P Mecham

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Citations

Jan 5, 2001·Bulletin of Experimental Biology and Medicine·V K KhavinsonV G Morozov
Oct 15, 2005·Bulletin of Experimental Biology and Medicine·T B KazakovaE A Korneva
Dec 13, 2006·Bulletin of Experimental Biology and Medicine·S V BarabanovaE A Korneva
Oct 16, 2009·Biogerontology·Vladimir N Anisimov, Vladimir Kh Khavinson
Apr 27, 1999·Immunology Letters·V I DeiginT N Semenets
Jun 19, 2001·Experimental Gerontology·V N Anisimov
May 10, 2012·Fiziologiia cheloveka·V Kh Khavinson, N S Lin'kova
Sep 5, 2002·International Journal of Cancer. Journal International Du Cancer·Vladimir N AnisimovClaudio Franceschi
Jul 8, 2003·International Journal of Cancer. Journal International Du Cancer·D Lynne SmithParkash S Gill
Feb 23, 2019·International Journal of Immunopathology and Pharmacology·Sergio CaputiVladimir Khavinson
Nov 28, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Vladimir Khatskelevich KhavinsonAnastasiia Romanovna Ilina

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