Natural Anti-biofilm Agents: Strategies to Control Biofilm-Forming Pathogens

Frontiers in Microbiology
Rojita MishraJunaid Khan

Abstract

Pathogenic microorganisms and their chronic pathogenicity are significant concerns in biomedical research. Biofilm-linked persistent infections are not easy to treat due to resident multidrug-resistant microbes. Low efficiency of various treatments and in vivo toxicity of available antibiotics drive the researchers toward the discovery of many effective natural anti-biofilm agents. Natural extracts and natural product-based anti-biofilm agents are more efficient than the chemically synthesized counterparts with lesser side effects. The present review primarily focuses on various natural anti-biofilm agents, i.e., phytochemicals, biosurfactants, antimicrobial peptides, and microbial enzymes along with their sources, mechanism of action via interfering in the quorum-sensing pathways, disruption of extracellular polymeric substance, adhesion mechanism, and their inhibitory concentrations existing in literature so far. This study provides a better understanding that a particular natural anti-biofilm molecule exhibits a different mode of actions and biofilm inhibitory activity against more than one pathogenic species. This information can be exploited further to improve the therapeutic strategy by a combination of more than one natu...Continue Reading

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Citations

Apr 8, 2021·ACS Biomaterials Science & Engineering·Deepa GargAbhay Sachdev
Apr 11, 2021·Applied and Environmental Microbiology·A EregaI Mandic Mulec
Jul 3, 2021·Microorganisms·Arianna PompilioCecilia Ambrosi
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Aug 11, 2021·Wiley Interdisciplinary Reviews. Nanomedicine and Nanobiotechnology·Brinta BhattacharjeeJayanta Haldar

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Methods Mentioned

BETA
RNA-seq
gene knockout

Clinical Trials Mentioned

NCT03196219

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