Natural Antibodies: from First-Line Defense Against Pathogens to Perpetual Immune Homeostasis

Clinical Reviews in Allergy & Immunology
Mohan S MaddurSrini V Kaveri

Abstract

Natural antibodies (nAbs) are most commonly defined as immunoglobulins present in the absence of pathological conditions or deliberate immunizations. Occurrence of nAbs in germ- and antigen-free mice suggest that their production is driven, at least in part, by self-antigens. Accordingly, nAbs are constituted of natural autoantibodies (nAAbs), and can belong to the IgM, IgG, or IgA subclasses. These nAbs provide immediate protection against infection while the adaptive arm of the immune system mounts a specific and long-term response. Beyond immediate protection from infection, nAbs have been shown to play various functional roles in the immune system, which include clearance of apoptotic debris, suppression of autoimmune and inflammatory responses, regulation of B cell responses, selection of the B cell repertoires, and regulation of B cell development. These various functions of nAbs are afforded by their reactivity, which is broad, cross-reactive, and shown to recognize evolutionarily fixed epitopes shared between foreign and self-antigens. Furthermore, nAbs have unique characteristics that also contribute to their functional roles and set them apart from antigen-specific antibodies. In further support for the role of nAbs i...Continue Reading

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Citations

Jun 4, 2019·Clinical Reviews in Allergy & Immunology·Sophie HillionYves Renaudineau
Aug 10, 2019·American Journal of Physiology. Heart and Circulatory Physiology·Connor F LauleJean F Regal
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May 31, 2019·Clinical Reviews in Allergy & Immunology·Anne BordronYves Renaudineau
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Jun 6, 2019·Clinical Reviews in Allergy & Immunology·Amandine CharrasYves Renaudineau
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Jul 16, 2021·Frontiers in Immunology·Marta RibaCarme Pelegrí

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