PMID: 9076629Jan 1, 1997Paper

Natural anticoagulants and the liver

Journal of Gastroenterology and Hepatology
D J Castelino, H H Salem


The regulation of blood coagulation is dependent on a complex interplay between procoagulant, anticoagulant and fibrinolytic proteins. Most of these proteins are synthesised in the liver and their levels are altered in patients with liver disease. The liver also plays an important role in the regulation of haemostasis throughout the clearance of activated clotting factors. It is therefore not surprising that the critically balanced coagulation system is dysregulated in patients with liver disease. In moderate liver failure bleeding disorders predominate, whereas in more advanced liver disease intravascular coagulation is commonly observed and contributes to the overall dysregulation of blood coagulation. In some patients, liver disease can be primarily caused by an abnormality of the coagulation system. These patients usually have a hypercoagulable state caused by a deficiency of a component of the natural anticoagulant system. These include protein C, protein S and antithrombin III. More recently, activated protein C resistance caused by a point mutation in the Factor V gene has been identified as an important risk factor for thrombosis. In these patients the abnormal Factor V is resistant to cleavage by activated protein C re...Continue Reading


Apr 1, 1987·Proceedings of the National Academy of Sciences of the United States of America·G J Broze, J P Miletich
Dec 1, 1988·Blood Reviews·C H Beresford
Apr 2, 1974·Archives of Biochemistry and Biophysics·G F Briginshaw, J N Shanberge
Jan 1, 1968·Scandinavian Journal of Clinical and Laboratory Investigation·U Abildgaard
Jan 1, 1994·Seminars in Thrombosis and Hemostasis·R J OldsS L Thein
Jan 1, 1994·Seminars in Thrombosis and Hemostasis·S T Olson, I Björk
Jan 1, 1994·Seminars in Thrombosis and Hemostasis·W F Novotny
Jan 1, 1994·Seminars in Thrombosis and Hemostasis·R L Bick, M Pegram
Sep 1, 1994·The Journal of Clinical Investigation·B Dahlbäck
May 1, 1994·The Medical Clinics of North America·E F Mammen
Jan 1, 1993·Seminars in Thrombosis and Hemostasis·J A Páramo, E Rocha
Jan 1, 1993·Seminars in Thrombosis and Hemostasis·G HimmelreichH Riess
Jan 1, 1957·Scandinavian Journal of Clinical and Laboratory Investigation·H HORTLING, L HIISI-BRUMMER

❮ Previous
Next ❯


Jul 23, 1999·Cardiovascular and Interventional Radiology·D Y SzeM D Dake
Jul 8, 2010·Transplantation·Burcin EkserBruno Gridelli
Apr 30, 2008·Digestive Diseases and Sciences·David GulleySuthat Liangpunsakul
Nov 29, 2012·The American Journal of the Medical Sciences·Xingshun QiGuohong Han
Mar 27, 2012·Hepatology Research : the Official Journal of the Japan Society of Hepatology·Shun KohsakaKeiichi Fukuda
Apr 21, 2004·Journal of the American Academy of Dermatology·Severine M ChavelJeffrey S Schechner
Apr 18, 2003·Critical Care Clinics·Anatoli KraskoSteven Bonvino
Sep 3, 1999·The Australian and New Zealand Journal of Surgery·R W Strong
Oct 19, 2012·Clinical and Applied Thrombosis/hemostasis : Official Journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis·Zhineng J YangRoy E Smith
Jul 26, 2006·The American Journal of Gastroenterology·Patrick G NorthupCarl L Berg
Sep 29, 2006·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Stephen H CaldwellUNKNOWN Coagulation in Liver Disease Group
Jun 23, 2005·Blood Coagulation & Fibrinolysis : an International Journal in Haemostasis and Thrombosis·Abeer K Al GhumlasFaleh Z Al Faleh
Feb 23, 2008·Current Eye Research·Jiri Rehak, Matus Rehak
May 12, 2017·Nature Reviews. Disease Primers·Michael KasperkiewiczMasayuki Amagai
May 5, 2020·Journal of Biomedical Materials Research. Part a·Chitra ShivalingamBalakumar Subramanium
Feb 11, 2020·JHEP Reports : Innovation in Hepatology·Laura TurcoErica Villa

❮ Previous
Next ❯

Related Concepts

Related Feeds

Blood Clotting Disorders

Thrombophilia includes conditions with increased tendency for excessive blood clotting. Blood clotting occurs when the body has insufficient amounts of specialized proteins that make blood clot and stop bleeding. Here is the latest research on blood clotting disorders.

ApoE, Lipids & Cholesterol

Serum cholesterol, triglycerides, apolipoprotein B (APOB)-containing lipoproteins (very low-density lipoprotein (VLDL), immediate-density lipoprotein (IDL), and low-density lipoprotein (LDL), lipoprotein A (LPA)) and the total cholesterol/high-density lipoprotein (HDL) cholesterol ratio are all connected in diseases. Here is the latest research.

Related Papers

Clinics in Liver Disease
S M Riordan, R Williams
Archives of Dermatology
D J Fader, S Kang
© 2021 Meta ULC. All rights reserved