Natural anticoagulants (antithrombin III, protein C, and protein S) in patients with mild to moderate ischemic stroke

Acta Neurologica Scandinavica
E HaapaniemiM Kaste

Abstract

The role of the natural anticoagulants, antithrombin III (AT III), protein C (PC), and protein S (PS), in patients with mild to moderate ischemic stroke remains uncertain. We aimed to find out whether their levels in peripheral blood correlated with the severity of neurological deficit or can predict clinical outcome and recurrence. We studied AT III, PC, and free PS levels in 55 consecutive patients likely to survive the study period on admission, 1 week, 1 month and 3 months after a first-ever ischemic stroke. Sex- and age-matched controls were studied once. All patients underwent a full neurological examination and blood sampling at each study time point; comprehensive stroke risk factors were recorded, and the etiology of the ischemic stroke was determined. All patients were contacted 3 years later for possible recurrent ischemic events. AT III level was found to be significantly lower at all time points after stroke; PC level was significantly increased on admission and normal at subsequent measurements, and PS level was normal on admission but significantly decreased later. The levels of the natural anticoagulants did not correlate with the etiology of stroke, any stroke risk factor, or neurological scores, except that th...Continue Reading

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Citations

Sep 17, 2002·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Chunming DongPascal J Goldschmidt-Clermont
Mar 6, 2007·Neuroimmunomodulation·Ali AkyolNefati Kiylioglu
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Jun 15, 2021·Frontiers in Neurology·Saiyet de la C BaezPedro Valdes-Sosa
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Dec 4, 2021·Frontiers in Cellular Neuroscience·Nelleke van der WeerdMarieke J H Wermer

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