Natural biocide cocktails: Combinatorial antibiotic effects of prodigiosin and biosurfactants

PloS One
Jennifer Hage-HülsmannAnita Loeschcke

Abstract

Bacterial secondary metabolites are naturally produced to prevail amongst competitors in a shared habitat and thus represent a valuable source for antibiotic discovery. The transformation of newly discovered antibiotic compounds into effective drugs often requires additional surfactant components for drug formulation. Nature may also provide blueprints in this respect: A cocktail of two compounds consisting of the antibacterial red pigment prodigiosin and the biosurfactant serrawettin W1 is naturally produced by the bacterium Serratia marcescens, which occurs in highly competitive habitats including soil. We show here a combinatorial antibacterial effect of these compounds, but also of prodigiosin mixed with other (bio)surfactants, against the soil-dwelling bacterium Corynebacterium glutamicum taken as a model target bacterium. Prodigiosin exerted a combinatorial inhibitory effect with all tested surfactants in a disk diffusion assay which was especially pronounced in combination with N-myristoyltyrosine. Minimal inhibitory and bactericidal concentrations (MIC and MBC) of the individual compounds were 2.56 μg/mL prodigiosin and 32 μg/mL N-myristoyltyrosine, and the MIC of prodigiosin was decreased by 3 orders of magnitude to 0....Continue Reading

References

Aug 1, 1987·European Journal of Clinical Microbiology·A M HorrevortsK F Kerrebijn
Sep 15, 1965·Experientia·M M ShemyakinI A Pavlenko
Sep 1, 1997·Nucleic Acids Research·S F AltschulD J Lipman
Jun 14, 2003·The Journal of Antimicrobial Chemotherapy·F C Odds
Sep 13, 2003·Proceedings of the National Academy of Sciences of the United States of America·Gregory L Challis, David A Hopwood
Mar 17, 2004·Biotechnology and Applied Biochemistry·Xuedong WangWangyu Tong
Jun 16, 2004·Current Opinion in Microbiology·Swaranjit Singh Cameotra, Randhir S Makkar
Nov 6, 2004·Applied and Environmental Microbiology·Sean F BradyJon Clardy
Apr 1, 1982·Applied and Environmental Microbiology·J S FengJ C Tsang
Nov 8, 2006·Applied and Environmental Microbiology·Alexandre JoussetClaudio Valverde
Dec 13, 2006·Nature Biotechnology·Jon ClardyChristopher T Walsh
Nov 29, 2007·Future Microbiology·Neil R WilliamsonGeorge P C Salmond
Feb 29, 2008·Journal of Natural Products·Deepti DwivediVictor Wray
Dec 23, 2008·Biochimica Et Biophysica Acta·Anne H Delcour
Feb 18, 2009·FEMS Microbiology Ecology·Henry MüllerGabriele Berg
Aug 22, 2009·Current Opinion in Microbiology·Michael A Fischbach
Oct 27, 2009·AAPS PharmSciTech·Pratap S JadonNarayanan Ganesh
Oct 28, 2009·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·James H Jorgensen, Mary Jane Ferraro
Feb 18, 2010·Molecular Cell·Michael A KohanskiJames J Collins
Mar 26, 2010·Applied Microbiology and Biotechnology·Ahmad Mohammad Abdel-MawgoudEric Déziel
May 11, 2010·Cold Spring Harbor Perspectives in Biology·Thomas J SilhavySuzanne Walker
May 13, 2010·Current Medicinal Chemistry·R Pérez-Tomás, M Viñas
Jun 11, 2010·Proceedings of the National Academy of Sciences of the United States of America·Pedro N LeãoWilliam H Gerwick
Sep 11, 2010·Methods in Molecular Biology·Sonja Christina TroeschelKarl-Erich Jaeger
Sep 9, 2011·Current Opinion in Microbiology·Michael A Fischbach
Nov 22, 2011·Emerging Infectious Diseases·Olivier BarraudMarie-Cécile Ploy
Jan 4, 2013·Angewandte Chemie·Nathalie Busschaert, Philip A Gale
Jan 5, 2013·Science·Yuichi WakamotoJohn D McKinney
Jun 1, 2010·Environmental Microbiology Reports·Jolien D'aesMonica Höfte
Dec 21, 2013·Microbial Cell Factories·Héctor RodríguezRamón I Santamaría
Mar 20, 2014·Current Opinion in Biotechnology·Alexander GrünbergerDietrich Kohlheyer

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Citations

Feb 15, 2019·Applied Microbiology and Biotechnology·Zhongyu YouWenjing Wu
Nov 21, 2018·Applied Microbiology and Biotechnology·T ClementsW Khan
Nov 17, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Chiara CeresaLetizia Fracchia
Sep 26, 2020·Frontiers in Bioengineering and Biotechnology·Sonja KubickiKarl-Erich Jaeger
Dec 2, 2020·Antibiotics·A MeretoudiS K Hadjikakou
Jun 5, 2020·Current Opinion in Biotechnology·Anita Loeschcke, Stephan Thies
Dec 5, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Katarzyna RajkowskaScott G Mitchell
Dec 8, 2020·Frontiers in Bioengineering and Biotechnology·Vera OrtseifenAlexander Grünberger
May 1, 2021·Microorganisms·Rodrigo Salazar Celedón, Leticia Barrientos Díaz

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Methods Mentioned

BETA
column chromatography
chip

Software Mentioned

antiSmash
ImageJ
BLAST P

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