Natural cocoa consumption: Potential to reduce atherogenic factors?

The Journal of Nutritional Biochemistry
Brian K McFarlinDavid W Hill

Abstract

Short-term consumption of flavanol-rich cocoa has been demonstrated to improve various facets of vascular health. The purpose of the present study was to determine the effect of 4 weeks of natural cocoa consumption on selected cardiovascular disease (CVD) biomarkers in young (19-35 years) women of differing body mass indices (BMI; normal, overweight or obese). Subjects (n = 24) consumed a natural cocoa-containing product (12.7 g natural cocoa, 148 kcal/serving) or an isocaloric cocoa-free placebo daily for 4 weeks in a random, double-blind manner with a 2-week washout period between treatment arms. Fasted (>8-h) blood samples were collected before and after each 4-week period. Serum was analyzed to determine lipid profile (chemistry analyzer) and CVD biomarkers (26 biomarkers). EDTA-treated blood was used to assess monocytes (CD14, CD16, v11b and CD62L), while citrate-treated blood was used to measure changes in endothelial microparticles (EMPs; CD42a-/45-/144+) by flow cytometry. Natural cocoa consumption resulted in a significant decrease in haptoglobin (P = .034), EMP concentration (P = .017) and monocyte CD62L (P = .047) in obese compared to overweight and normal-weight subjects. Natural cocoa consumption regardless of BMI ...Continue Reading

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Citations

Sep 14, 2016·Methods : a Companion to Methods in Enzymology·Brian K McFarlin, Melody A Gary
Dec 22, 2016·European Journal of Clinical Nutrition·B K McFarlinA S Venable
Nov 11, 2017·Journal of the Science of Food and Agriculture·Blanca Escudero-LópezMaría-Soledad Fernández-Pachón
Jan 6, 2017·Current Protocols in Cytometry·Andrea L HenningBrian K McFarlin
Sep 22, 2017·Diseases·Ana Clara AprotosoaieIrina-Iuliana Costache
Mar 16, 2021·Frontiers in Cardiovascular Medicine·Che Mohd Nasril Che Mohd NassirMuzaimi Mustapha
Jul 12, 2019·Journal of Agricultural and Food Chemistry·Michael GröneChristian Heiss

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