Natural Compounds as Anticancer Agents Targeting DNA Topoisomerases

Current Genomics
Chetan Kumar JainSusanta Roychoudhury

Abstract

DNA topoisomerases are important cellular enzymes found in almost all types of living cells (eukaryotic and prokaryotic). These enzymes are essential for various DNA metabolic processes e.g. replication, transcription, recombination, chromosomal decatenation etc. These enzymes are important molecular drug targets and inhibitors of these enzymes are widely used as effective anticancer and antibacterial drugs. However, topoisomerase inhibitors have some therapeutic limitations and they exert serious side effects during cancer chemotherapy. Thus, development of novel anticancer topoisomerase inhibitors is necessary for improving cancer chemotherapy. Nature serves as a repertoire of structurally and chemically diverse molecules and in the recent years many DNA topoisomerase inhibitors have been identified from natural sources. The present review discusses anticancer properties and therapeutic importance of eighteen recently identified natural topoisomerase inhibitors (from the year 2009 to 2015). Structural characteristics of these novel inhibitors provide backbones for designing and developing new anticancer drugs.

Citations

Nov 30, 2019·Journal of Clinical Biochemistry and Nutrition·Hye-Jeong KwonSung-Dae Cho
Jul 14, 2020·Frontiers in Cellular and Infection Microbiology·Sergio O AngelWilliam J Sullivan
Sep 26, 2020·Journal of Enzyme Inhibition and Medicinal Chemistry·Kamila BuzunAgnieszka Gornowicz
Aug 23, 2019·DNA Repair·Karin C NitissLeslyn A Hanakahi
Apr 4, 2021·International Journal of Molecular Sciences·Magdalena KluskaKatarzyna Woźniak
May 1, 2021·International Journal of Molecular Sciences·Alessio OttavianiAlessandro Desideri
May 1, 2021·International Journal of Molecular Sciences·Virginia BrighentiFederica Pellati

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Methods Mentioned

BETA
acetylation
DNA cleavage assay
sumoylation
xenograft

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