Natural compounds with aromatase inhibitory activity: an update.

Planta medica
Marcy J Balunas, A Douglas Kinghorn

Abstract

Several synthetic aromatase inhibitors are currently in clinical use for the treatment of postmenopausal women with hormone-receptor positive breast cancer. However, these treatments may lead to untoward side effects and so the search for new aromatase inhibitors continues, especially those for which the activity is promoter-specific, targeting the breast-specific promoters I.3 and II. Recently, numerous natural compounds have been found to inhibit aromatase in noncellular, cellular, and IN VIVO studies. These investigations, covering the last two years, as well as additional studies that have focused on the evaluation of natural compounds as promoter-specific aromatase inhibitors or as aromatase inducers, are described in this review.

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Citations

Jul 31, 2012·Journal of Agricultural and Food Chemistry·Dan-feng LuGuo-lin Zhang
Jun 23, 2011·Reproductive Biology and Endocrinology : RB&E·Shabana I KhanAsok K Dasmahapatra
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Jun 11, 2021·Journal of Natural Products·Pornsuda ChawengrumSomsak Ruchirawat

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