Natural course of adult-onset vitelliform lesions in eyes with and without comorbid subretinal drusenoid deposits.

International Ophthalmology
Craig WildeWinfried M K Amoaku

Abstract

Adult vitelliform lesions (AVL) are associated with age related macular degeneration (AMD) and subretinal drusenoid deposits (SRDD). We evaluated the natural course of AVL, assessing the influence of SRDD on disease progression, visual function and incidence of macular atrophy (MA) and choroidal neovascular membranes (CNVM). A retrospective cohort study was conducted between January 2011 and March 2016. Demographic, clinical and imaging data from 26 consecutive AVL patients were analysed following case note review. Optical coherence tomography images were graded for SRDD and patients divided into those with/without SRDD. Outcomes included presenting/changes in best corrected visual acuity (BCVA) and incidence of MA/CNVM. Mean age was 78.6 ± 7.6 years. Mean follow-up was 51.5 ± 25.6 months. Twelve patients (46.2%) had SRDD at presentation with 3 more (11.5%) developing them. Subjects with SRDD were older (mean 81.7 ± 6.1 years vs 74.3 ± 7.6 years, p = 0.010). Mean presenting BCVA was worse in SRDD eyes (0.39 ± 0.31 logMAR vs 0.19 ± 0.18 logMAR, p = 0.017). Eight of 15 patients with SRDD (53.3%) developed incident MA or CNVM; higher than those with no SRDD (1/11, 9.1%; p = 0.036). Two patients (7.7%) developed full thickness macu...Continue Reading

References

May 1, 1990·Australian and New Zealand Journal of Ophthalmology·A H GreavesS H Sarks
Nov 30, 2007·American Journal of Ophthalmology·Ronald KleinBarbara E K Klein
Jan 24, 2016·The British Journal of Ophthalmology·Liran TiosanoItay Chowers
Sep 19, 2016·American Journal of Ophthalmology·Chandrakumar BalaratnasingamK Bailey Freund

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Citations

Aug 15, 2021·Ophthalmology Retina·Shruti ChandraSobha Sivaprasad

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Methods Mentioned

BETA
genotyping

Software Mentioned

statistical package for the social sciences ( SPSS )
SDOCT

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