Natural course of small adrenal lesions in multiple endocrine neoplasia type 1: an endoscopic ultrasound imaging study

European Journal of Endocrinology
S SchaeferP H Kann

Abstract

Adrenal lesion is one of the features of multiple endocrine neoplasia type 1 (MEN1). This study aimed to assess prevalence, natural course and clinical relevance of small adrenal lesions without clinical symptoms, endocrine activity, or mechanical problems and thus without clear indication for surgical therapy by endoscopic ultrasound (EUS). Forty-nine patients with familial MEN1 were studied. Twenty-seven of these with adrenal lesions were detected by EUS and at least two performed EUS examinations were included into a subgroup where changes in adrenal morphology were studied by measuring changes in the largest diameter of the dominant adrenal tumour. EUS detected adrenal lesions in 36 (73%) patients: 6 (12%) plump adrenals, 17 (35%) nodular hyperplasia, 12 (24%) adenomas and 1 (2%) cyst. Bilateral adrenal lesions were detected in 17 patients and unilateral in 19 patients. A change in the largest tumour diameter was found to be for nodular hyperplasia -0.02+/-1.41% per month (range -2.56 to 4.58%) and for adenomas -0.61+/-1.95% per month (range -6.25 to 1.15%). One patient had an adrenal cyst with significant growth. There was no evidence of carcinoma or metastatic disease during the study. The prevalence of adrenal lesions in...Continue Reading

Citations

Mar 4, 2011·JRSM Short Reports·Karunakaran VithianSabina Russell
Nov 16, 2011·European Journal of Endocrinology·B Gatta-CherifiA Tabarin
Jun 17, 2014·Seminars in Pediatric Surgery·Gerard V Walls
Dec 20, 2008·Der Chirurg; Zeitschrift für alle Gebiete der operativen Medizen·P E GoretzkiB J Lammers
Apr 5, 2012·Clinical Endocrinology·Tânia L MazzucoIsabelle Bourdeau
Jan 3, 2013·Asia-Pacific Journal of Clinical Oncology·Richard W Carroll
Oct 14, 2014·Endocrinology and Metabolism·Yoon Jung ChungYumie Rhee
Aug 5, 2017·Endocrine-related Cancer·Rachel S van LeeuwaardeGerlof D Valk
Sep 12, 2014·F1000Research·Joanna MatrozovaSabina Zacharieva
Sep 12, 2014·F1000Research·Joanna MatrozovaSabina Zacharieva
Jul 1, 2009·Expert Review of Endocrinology & Metabolism·Cornelis Jm LipsJo Wm Höppener
Jun 23, 2012·The Journal of Clinical Endocrinology and Metabolism·Rajesh V ThakkerUNKNOWN Endocrine Society
Mar 23, 2017·World Journal of Surgery·Jerena ManoharanDetlef K Bartsch
Sep 5, 2019·Archives of Endocrinology and Metabolism·Mara VenturaFrancisco Carrilho
Jul 3, 2019·Frontiers in Endocrinology·Crystal D C Kamilaris, Constantine A Stratakis
Feb 11, 2021·Nature Reviews. Endocrinology·Abdallah Al-SalamehPhilippe Chanson
Jul 16, 2021·Endocrine Practice : Official Journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists·Edwina C MooreSusannah Ahern
Aug 12, 2021·Therapeutic Advances in Endocrinology and Metabolism·Christine NewmanMarcia Bell
Dec 2, 2021·The Journal of Clinical Endocrinology and Metabolism·Michael R ClayKatja Kiseljak-Vassiliades

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Proceedings of the National Academy of Sciences of the United States of America
S C GuruSettara C Chandrasekharappa
© 2022 Meta ULC. All rights reserved