Natural course of the impairment of endothelium-dependent relaxations after balloon endothelium removal in porcine coronary arteries. Possible dysfunction of a pertussis toxin-sensitive G protein

Circulation Research
H ShimokawaP M Vanhoutte

Abstract

The purposes of the present study were to examine the natural course of the impairment of endothelium-dependent relaxations during a regeneration and tissue repair process after balloon endothelium removal and to elucidate the cellular mechanism(s) underlying it. Twenty-three male Yorkshire pigs underwent balloon endothelium removal along the proximal portion of either the left anterior descending or circumflex coronary artery and were then maintained on a regular chow for 4, 8, 16, or 24 weeks. Endothelium-dependent responses were examined in vitro in rings taken from the control and previously denuded arteries studied in parallel. Morphometric analysis revealed that intimal thickening developed only at the previously denuded area. In the previously denuded arteries with regenerated endothelium, the endothelium-dependent relaxations to UK 14304 (a selective alpha 2-adrenergic agonist), serotonin, and aggregating platelets were impaired 4 weeks after endothelium removal and remained so throughout the study. The endothelium-dependent relaxations to thrombin and adenosine diphosphate became depressed 8 weeks after endothelium removal and those to bradykinin became depressed 16 weeks after endothelium removal, while those to the c...Continue Reading

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Citations

Jan 1, 1990·Cardiovascular Drugs and Therapy·P M Vanhoutte
Aug 7, 2010·Cardiovascular Drugs and Therapy·Paul M Vanhoutte
Apr 12, 2008·Purinergic Signalling·Cheikh I SeyeGary A Weisman
Apr 12, 2008·Purinergic Signalling·Cheikh I SeyeGary A Weisman
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Mar 18, 2004·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Michel Félétou, Paul M Vanhoutte
Nov 1, 1996·Progress in Cardiovascular Diseases·P M Vanhoutte, J V Mombouli
Jan 1, 1997·Progress in Cardiovascular Diseases·G R De Meyer, A G Herman
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