Natural cycle IVF reduces the risk of low birthweight infants compared with conventional stimulated IVF

Human Reproduction
Winifred MakMark Payson

Abstract

Are perinatal outcomes improved in singleton pregnancies resulting from fresh embryo transfers performed following unstimulated/natural cycle IVF (NCIVF) compared with stimulated IVF? Infants conceived by unstimulated/NCIVF have a lower risk of being low birthweight than infants conceived by stimulated IVF; however, this risk did not remain significant after adjusting for gestation age. Previous studies have shown that infants born after modified NCIVF have a higher average birthweight and are less likely to be low birthweight than those infants conceived with conventional stimulated IVF. Retrospective cohort study of singleton live births in non-smoking women undergoing fresh IVF-embryo transfer cycles from 2007 to 2013 in a single IVF center. The women were stratified by stimulated (n = 174) or unstimulated (n = 190) IVF exposure status. Unstimulated/NCIVF is defined as IVF without the use of exogenous gonadotrophins, and only includes the use of HCG to time oocyte retrieval. Demographic data including maternal age, BMI, infertility diagnosis and IVF cycle characteristics were collected. The perinatal outcomes used for comparison between the two study groups were length of gestation, birthweight, preterm delivery, very preter...Continue Reading

References

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Citations

Apr 19, 2017·Journal of Developmental Origins of Health and Disease·M Chen, L K Heilbronn
Mar 31, 2018·Systems Biology in Reproductive Medicine·Linjun ChenHaixiang Sun
Jan 17, 2019·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Yu WuXiaowei Xi
Aug 9, 2019·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Limei ZhangCanquan Zhou
Jul 22, 2018·Journal of Assisted Reproduction and Genetics·Junshun FangLinjun Chen
Apr 30, 2017·Archives of Gynecology and Obstetrics·Lucia CardellicchioWalter Vegetti
Oct 12, 2019·Free Radical Biology & Medicine·Irantzu Pérez-RuizJosé-Ignacio Ruiz-Sanz
Aug 20, 2021·Molecular Reproduction and Development·Jianhua ZhangXiaohong Wang
Jul 5, 2018·Pediatrics·Sunah S HwangJudy E Stern

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