Natural cytotoxicity toward K562 cells by macaque lymphocytes from infancy through puberty: effects of early social challenge

Brain, Behavior, and Immunity
M L LaudenslagerM Reite

Abstract

The consequences of a single maternal separation experience followed by reunion at 6-7 months of age was studied in socially housed pigtail (Macaca nemestrina) and bonnet (Macaca radiata) macaques. At 15 months, these subjects were removed from their natal group and placed in same species social groups, consisting of other separated and matched control subjects. Some subjects were followed until they reached an average age of 4 years while remaining in this group. Blood samples were drawn to permit assessment of the ability of peripheral blood lymphocytes to lyse, in vitro, K562 cells. Maternal separation failed to affect lysis of K562 cells acutely, although lysis by matched control subjects appeared to be transiently reduced 2 h after removal of the adult female. A longer-term influence was noted such that lysis of targets in previously separated subjects was greater than that in matched controls. Lysis rose over time regardless of species or experimental condition. A striking internal consistency in the lysis was also noted. Lysis was highly intercorrelated (r's > .60, p < or = .005) within subjects across time during baseline, separation, and reunion phases of the acute social challenge. In addition, there was a tendency fo...Continue Reading

Citations

May 26, 2009·Brain, Behavior, and Immunity·Suzanne C Segerstrom, Mark L Laudenslager
Jan 8, 2009·Journal of the American Academy of Child and Adolescent Psychiatry·Hanna E StevensStephen J Suomi
Apr 20, 2000·Applied Animal Behaviour Science·S J SchapiroK J Sastry

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