Natural disaster-related prenatal maternal stress is associated with alterations in placental glucocorticoid system: The QF2011 Queensland Flood Study

Psychoneuroendocrinology
Joey St-PierreCathy Vaillancourt

Abstract

We investigated the effects of a natural disaster (a sudden flood) as a source of prenatal maternal stress (PNMS) on the placental glucocorticoid system and glucose transporters. Whether the gestational age at the time of the flood moderated these effects was also evaluated. Placental samples were collected from participants in the 2011 Queensland Flood Study (QF2011) who were pregnant in the first or second trimester at the onset of the flood. Detailed questionnaire results for objective hardship and composite subjective distress were obtained to assess stress levels. Subjective distress was significantly associated with a reduction in placental NR3C1-β mRNA levels for males only (β = -0.491, p = 0.005). In female placentas, objective hardship was marginally linked with lower SLC2A1 mRNA levels while subjective distress was a marginally significant predictor of higher placental SLC2A4 mRNA levels. Gestational age at the time of the flood was a significant moderator of the effect of subjective distress on placental mRNA levels for NR3C1-α (p = 0.046) and HSD11B1 (p = 0.049) in male placentas: if the flood occurred in mid-pregnancy, lower subjective distress predicted higher HSD11B1 while higher subjective distress predicted low...Continue Reading

Citations

Sep 16, 2019·Current Psychiatry Reports·Emily LipnerLauren M Ellman
Oct 11, 2019·Obstetrics and Gynecology·Hector Mendez-FigueroaKjersti Aagaard
Jan 22, 2020·Upsala Journal of Medical Sciences·Åsa EdvinssonSusanne Lager
Feb 8, 2019·Current Psychiatry Reports·Laurel M HicksElysia Poggi Davis
Sep 18, 2021·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Vasily N AushevJia Chen

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