Natural feline coronavirus infection: differences in cytokine patterns in association with the outcome of infection.

Veterinary Immunology and Immunopathology
A KiparM Reinacher

Abstract

Natural and experimental feline coronavirus (FCoV) infection leads to systemic viral spread via monocyte-associated viraemia and induces systemic proliferation of monocytes/macrophages. In the majority of naturally infected animals, FCoV infection remains subclinical and is associated with generalised B and T cell hyperplasia, but no other pathological findings. A minority of cats, however, develop feline infectious peritonitis (FIP), a fatal systemic granulomatous disease. This is generally accompanied by B and T cell depletion. The obvious functional differences of lymphatic tissues in FCoV-infected cats with and without FIP suggest that they contribute to the outcome of FCoV infection. This study attempted to evaluate the functional changes in haemolymphatic tissues after natural FCoV infection, with special emphasis on the magnitude, phenotype and function of the monocyte/macrophage population. The spleen, mesenteric lymph nodes and bone marrow from naturally FCoV-infected cats with and without FIP and specific pathogen-free (SPF) control cats were examined for the quantity and activation state of monocytes/macrophages both by immunohistology and by quantitative real time PCR for the transcription of interleukin (IL)-1beta,...Continue Reading

Citations

Mar 4, 2009·Journal of Feline Medicine and Surgery·Niels C Pedersen
May 5, 2010·Journal of the American Animal Hospital Association·Kristin M Lewis, Robert T O'Brien
Jul 29, 2010·Veterinary Research·Liesbeth VogelPeter J M Rottier
Feb 27, 2014·Veterinary Pathology·A Kipar, M L Meli
Nov 17, 2019·Viruses·Sandra Felten, Katrin Hartmann
Oct 1, 2009·Emerging Infectious Diseases·Meredith A BrownStephen J O'Brien
Apr 4, 2012·Viruses·Stephen J O'BrienJill Pecon-Slattery
Feb 9, 2012·Advances in Virology·Luciana Wanderley MyrrhaMárcia Rogéria de Almeida
Sep 4, 2008·American Journal of Veterinary Research·Melissa A KennedyStephen A Kania
Dec 1, 2018·PloS One·Luisa Helena Monteiro de MirandaRegina Hofmann-Lehmann
Apr 12, 2008·Acta Veterinaria Hungarica·Sándor HornokBéla Lakatos
Sep 29, 2020·Transboundary and Emerging Diseases·Saverio PaltrinieriStefania Lauzi
Mar 12, 2021·Virus Research·Santiago Emanuel ColinaGermán Ernesto Metz
Nov 23, 2020·Acta Veterinaria Hungarica·Eva Schmal-FiliusHerbert Weissenböck
Jun 27, 2009·Veterinary Immunology and Immunopathology·Henriëtte E Booij-VrielingHerman A W Hazewinkel

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Datasets Mentioned

BETA
GM-CSF

Methods Mentioned

BETA
PCR
light microscopy

Software Mentioned

BMDP

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