Natural genetic variation in lycopene epsilon cyclase tapped for maize biofortification.

Science
Carlos E HarjesEdward S Buckler

Abstract

Dietary vitamin A deficiency causes eye disease in 40 million children each year and places 140 to 250 million at risk for health disorders. Many children in sub-Saharan Africa subsist on maize-based diets. Maize displays considerable natural variation for carotenoid composition, including vitamin A precursors alpha-carotene, beta-carotene, and beta-cryptoxanthin. Through association analysis, linkage mapping, expression analysis, and mutagenesis, we show that variation at the lycopene epsilon cyclase (lcyE) locus alters flux down alpha-carotene versus beta-carotene branches of the carotenoid pathway. Four natural lcyE polymorphisms explained 58% of the variation in these two branches and a threefold difference in provitamin A compounds. Selection of favorable lcyE alleles with inexpensive molecular markers will now enable developing-country breeders to more effectively produce maize grain with higher provitamin A levels.

References

Nov 1, 1996·Genetics·A MochizukiY Iwasa
Dec 29, 2000·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·B J Pogson, H M Rissler
Jan 5, 2001·Nutrition Reviews·C E West
Sep 20, 2001·Proceedings of the National Academy of Sciences of the United States of America·D L RemingtonE S Buckler
Sep 11, 2002·The Journal of Nutrition·Omar DaryUNKNOWN International Vitamin A Consultative Group
Sep 2, 2003·The Journal of Nutrition·Jose O Mora
Oct 3, 2003·TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik·J C WongT R Rocheford
Jan 6, 2004·The Journal of Nutrition·Barbara A Underwood
Mar 9, 2004·Progress in Lipid Research·Paul D Fraser, Peter M Bramley
May 27, 2004·Proceedings of the National Academy of Sciences of the United States of America·Kelly PalaisaAntoni Rafalski
Apr 9, 2005·The American Journal of Clinical Nutrition·Machteld van Lieshout, Saskia de Pee
Dec 20, 2005·The Plant Journal : for Cell and Molecular Biology·Sherry A Flint-GarciaEdward S Buckler
May 4, 2006·Annual Review of Plant Biology·Dean DellaPenna, Barry J Pogson
Sep 22, 2006·The Journal of Nutrition·Julie A Howe, Sherry A Tanumihardjo
Apr 17, 2007·Plant Physiology·Faqiang LiEleanore T Wurtzel

❮ Previous
Next ❯

Citations

Oct 23, 2009·TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik·Benjamin StichAlbrecht E Melchinger
Nov 4, 2009·TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik·Zhiyuan FuJian-Sheng Li
Mar 30, 2010·TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik·Xiaohong YangJiansheng Li
Apr 23, 2010·TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik·Jérémy ClotaultDidier Peltier
Sep 30, 2010·TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik·Lu WangBin Han
Mar 28, 2012·TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik·Xuecai ZhangJiankang Wang
May 23, 2012·TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik·Tobias Würschum
Oct 12, 2012·TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik·Raman BabuKevin Pixley
Nov 6, 2012·TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik·Yelena BorovskyIlan Paran
Dec 15, 2012·TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik·Zhiyuan FuJianbing Yan
Sep 18, 2013·TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik·Catherine B KandianisTorbert Rocheford
Jun 26, 2012·Planta·Shuiqin WuJoe Chappell
Nov 6, 2009·Molecular Genetics and Genomics : MGG·Neetu ChaudharyParamjit Khurana
Mar 19, 2013·Plant Molecular Biology·Ralph Bock
May 11, 2011·Indian Pediatrics·Sandeep SachdevaNajam Khalique
Jul 16, 2013·Archives of Biochemistry and Biophysics·Li Li, Hui Yuan
Jul 24, 2013·Archives of Biochemistry and Biophysics·Manuel Rodriguez-Concepcion, Claudia Stange
May 23, 2013·Journal of Agricultural and Food Chemistry·Tristan E LipkieMario G Ferruzzi
Jun 19, 2013·Journal of Agricultural and Food Chemistry·Ángeles ObreroBelén Román
Jun 19, 2013·Journal of Agricultural and Food Chemistry·Camilla Z GallonTimothy J O'Hare
Mar 7, 2013·Heredity·J G WallaceE S Buckler
Dec 18, 2013·Nature Communications·Junjie FuGuoying Wang
Feb 29, 2008·Nature Genetics·Dani Zamir
Oct 29, 2010·Nature Genetics·Richard M Clark
May 7, 2009·Proceedings of the National Academy of Sciences of the United States of America·Shaista NaqviPaul Christou
Oct 27, 2010·Proceedings of the National Academy of Sciences of the United States of America·Yanli LuYunbi Xu
Mar 22, 2012·Omics : a Journal of Integrative Biology·K D NadellaP Ananda Kumar
Jan 8, 2010·Briefings in Functional Genomics·David HallPär K Ingvarsson
Jun 1, 2011·Database : the Journal of Biological Databases and Curation·Mary L SchaefferCarolyn J Lawrence
Aug 30, 2008·Journal of Experimental Botany·Maneesha AluruSteve Rodermel
Jul 4, 2009·Journal of Experimental Botany·Charles Ampomah-DwamenaAndrew C Allan
Apr 4, 2012·Plant & Cell Physiology·Ming-Zhu LvHong-Xuan Lin
Jul 10, 2008·Plant Physiology·Stephen P Moose, Rita H Mumm
Apr 7, 2009·Plant Physiology·Ratnakar Vallabhaneni, Eleanore T Wurtzel

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.