PMID: 36443Jul 1, 1979

Natural, genetically determined resistance toward influenza virus in hemopoietic mouse chimeras. Role of mononuclear phagocytes

The Journal of Experimental Medicine
O HallerJ Lindenmann


Radiation chimeras produced by crosswise transfers of bone-marrow cell among histocompatible mice susceptible, or genetically resistant, to lethal challenge by a number of myxoviruses were used to test whether macrophage resistance (as assessed in vitro) and resistance of the animal (as measured in vivo), both previously shown to be brought about by the gene Mx, were causally related. 49 chimeras were tested individually, both of resistance of their macrophages to in vitro challenge with M-TUR (a strain of avian influenza virus A/Turkey/England/63 adapted to grow in cultured mouse peritoneal macrophages), and for resistance of the animal in vivo upon challenge with pneumotropic, neurotropic, or hepatotropic influenza viruses. Cultivated Kupffer cells and peritoneal macrophages harvested from chimeric mice expressed the resistance phenotype of the bone-marrow donor irrespective of the host environment in which they had differentiated. However, susceptibility or resistance in vivo was according to the genotype of the host. Thus, inborn resistance of radiation chimeras was found to be independent of Mx-gene expression in cells of the hemopoietic system.


Feb 1, 1978·The Journal of Experimental Medicine·J LindenmannO Haller
Mar 1, 1979·The Journal of Experimental Medicine·O HallerJ Lindenmann
Oct 1, 1978·Proceedings of the Society for Experimental Biology and Medicine·P SheetsF B Bang
Jan 1, 1976·Experimental Cell Biology·H ArnheiterJ Lindenmann
May 1, 1977·The Journal of Experimental Medicine·O HallerH Wigzell
Jan 1, 1975·Archives of Virology·O Haller
Aug 23, 1974·Nature·O Haller, J Lindenmann
Sep 1, 1972·The Journal of Experimental Medicine·J J Godleski, J D Brain
May 1, 1968·The Journal of Experimental Medicine·M Virolainen
Feb 1, 1962·Proceedings of the National Academy of Sciences of the United States of America·G T GOODMAN, H KOPROWSKI
Jun 1, 1964·Proceedings of the Society for Experimental Biology and Medicine·J Lindenmann
Aug 1, 1960·Proceedings of the National Academy of Sciences of the United States of America·F B Bang, A Warwick


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Related Concepts

Colony-Forming Units, Hematopoietic
Resistance, Natural
Mice, Inbred Strains
Orthomyxoviridae Infections
Radiation Chimera
Transplantation, Homologous
Hemopoietic Stem Cell Transplant

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