PMID: 36443Jul 1, 1979

Natural, genetically determined resistance toward influenza virus in hemopoietic mouse chimeras. Role of mononuclear phagocytes

The Journal of Experimental Medicine
O HallerJ Lindenmann

Abstract

Radiation chimeras produced by crosswise transfers of bone-marrow cell among histocompatible mice susceptible, or genetically resistant, to lethal challenge by a number of myxoviruses were used to test whether macrophage resistance (as assessed in vitro) and resistance of the animal (as measured in vivo), both previously shown to be brought about by the gene Mx, were causally related. 49 chimeras were tested individually, both of resistance of their macrophages to in vitro challenge with M-TUR (a strain of avian influenza virus A/Turkey/England/63 adapted to grow in cultured mouse peritoneal macrophages), and for resistance of the animal in vivo upon challenge with pneumotropic, neurotropic, or hepatotropic influenza viruses. Cultivated Kupffer cells and peritoneal macrophages harvested from chimeric mice expressed the resistance phenotype of the bone-marrow donor irrespective of the host environment in which they had differentiated. However, susceptibility or resistance in vivo was according to the genotype of the host. Thus, inborn resistance of radiation chimeras was found to be independent of Mx-gene expression in cells of the hemopoietic system.

References

Feb 1, 1978·The Journal of Experimental Medicine·J LindenmannO Haller
Mar 1, 1979·The Journal of Experimental Medicine·O HallerJ Lindenmann
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Jan 1, 1976·Experimental Cell Biology·H ArnheiterJ Lindenmann
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Jun 1, 1964·Proceedings of the Society for Experimental Biology and Medicine·J Lindenmann
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Citations

Jan 1, 1983·Transactions of the Royal Society of Tropical Medicine and Hygiene·R van Furth, W Sluiter
Mar 16, 2000·Developmental and Comparative Immunology·D L Suarez, S Schultz-Cherry
Oct 1, 1982·Pathology, Research and Practice·R van Furth, A Blussé van Oud Alblas
Jan 1, 1984·Proceedings of the National Academy of Sciences of the United States of America·F BelardelliI Gresser
Dec 19, 2013·PLoS Pathogens·Bastian HatesuerKlaus Schughart
Aug 30, 2008·International Journal for Parasitology·Ute FrevertElizabeth Nardin
Mar 1, 1980·Clinical Immunology and Immunopathology·R M ZinkernagelA Althage
May 17, 2019·Journal of Virology·Jan SpitaelsXavier Saelens
Jan 1, 1981·Scandinavian Journal of Rheumatology. Supplement·R van Furth
Jun 28, 2018·Mammalian Genome : Official Journal of the International Mammalian Genome Society·Heike KollmusKlaus Schughart

Related Concepts

Colony-Forming Units, Hematopoietic
Resistance, Natural
Mice, Inbred Strains
Myxoviruses
Orthomyxoviridae Infections
Phagocytes
Radiation Chimera
Transplantation, Homologous
Hemopoietic Stem Cell Transplant

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