Natural history and management of esophagogastric varices in chronic noncirrhotic, nontumoral portal vein thrombosis

Hepatology : Official Journal of the American Association for the Study of Liver Diseases
Carlos Noronha FerreiraJuan-Carlos García-Pagan

Abstract

In patients with chronic noncirrhotic, nontumoral portal vein thrombosis (PVT), the usually recommended strategy for endoscopic screening and management of varices is the same as in cirrhosis. However, the efficacy of this policy in patients with PVT is unknown. We assessed the course of gastroesophageal varices in a large cohort of patients with chronic PVT. Patients prospectively registered in two referral centers for vascular liver disorders were eligible for the study. Endpoints were development and growth of varices and the incidence and outcome of portal hypertension-related bleeding. Included were 178 patients with chronic PVT. Median follow-up was 49 (1-598) months. Variceal bleeding was the initial manifestation in 27 (15%) patients. Initial endoscopy in the remaining 151 patients showed no varices in 52 (34%), small esophageal varices in 28 (19%), large esophageal varices (LEVs) in 60 (40%), and gastric varices without LEVs in 11 (7%). Ascites and splenomegaly were independent predictors for the presence of varices. In patients without varices, the probability of developing them was 2%, 22%, and 22% at 1, 3, and 5 years, respectively. In those with small esophageal varices, growth to LEVs was observed in 13%, 40%, and...Continue Reading

References

Dec 1, 1992·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·S K SarinU K Makwana
Feb 1, 1997·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·T KimM Okumura
Nov 24, 1999·The American Journal of Gastroenterology·A ZamanK Benner
Aug 29, 2000·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·B CondatD Valla
Dec 11, 2002·Journal of Gastroenterology and Hepatology·Kunio Okuda
Feb 15, 2003·Journal of Hepatology·Manuela MerliOliviero Riggio
Mar 22, 2003·Lancet·Jaume Bosch, Juan Carlos García-Pagán
May 30, 2003·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Juan Carlos García-PagánUNKNOWN Spanish Variceal Bleeding Study Group
Jul 5, 2003·Lancet·Ulrich ThalheimerAndrew K Burroughs
Jul 9, 2004·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Michael SchepkeUNKNOWN German Study Group for the Primary Prophylaxis of Variceal Bleeding
Aug 12, 2004·British Journal of Cancer·J M SatagopanA D Auerbach
Nov 25, 2005·The New England Journal of Medicine·Roberto J GroszmannUNKNOWN Portal Hypertension Collaborative Group
Dec 5, 2006·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·David W OrrMichael A Heneghan
Jun 15, 2007·Bone Marrow Transplantation·L ScruccaF Aversa
Sep 20, 2007·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Guadalupe Garcia-TsaoUNKNOWN Practice Parameters Committee of the American College of Gastroenterology
Oct 26, 2007·The American Journal of Gastroenterology·Lucio AmitranoAntonio Balzano
Feb 29, 2008·Journal of Hepatology·Jaime BoschJuan G Abraldes
Sep 25, 2008·Seminars in Liver Disease·Juan Carlos Garcia-PagánJaime Bosch
Jul 18, 2009·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Dhiraj TripathiPeter C Hayes
Sep 22, 2009·Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver·Massimo Primignani
Nov 2, 2011·Journal of Thrombosis and Haemostasis : JTH·J HoekstraH L A Janssen
Feb 4, 2012·Journal of Hepatology·Aurélie PlessierDominique-Charles Valla
Mar 17, 2015·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Federica CeriniJuan Carlos Garcia-Pagán
Oct 31, 2015·Journal of Hepatology·UNKNOWN European Association for the Study of the Liver. Electronic address: easloffice@easloffice.eu

❮ Previous
Next ❯

Citations

Nov 24, 2016·American Journal of Hematology·Lisa PieriAlessandro M Vannucchi
Jan 10, 2018·European Journal of Gastroenterology & Hepatology·Maeva GuillaumeChristophe Bureau
Feb 22, 2018·Hepatology International·Rajeev Khanna, Shiv Kumar Sarin
Jun 27, 2020·World Journal of Gastroenterology : WJG·Oana Nicoară-FarcăuBogdan Procopeț
Dec 31, 2019·Liver International : Official Journal of the International Association for the Study of the Liver·Anna BaigesJuan Carlos García-Pagán
Jun 28, 2018·Blood Cancer Journal·Guido FinazziTiziano Barbui
Oct 20, 2020·Internal and Emergency Medicine·Francesco VioliDaniele Pastori
Jan 12, 2021·Zeitschrift für Gastroenterologie·Simon J GairingJörn M Schattenberg
Nov 22, 2020·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Patrick G NorthupDominique C Valla
Oct 23, 2019·Annals of Vascular Surgery·Luca RoncatiAlberto Farinetti
Aug 21, 2020·Clinics and Research in Hepatology and Gastroenterology·Laure ElkriefChristophe Bureau
Jul 10, 2021·Liver International : Official Journal of the International Association for the Study of the Liver·Mattias MandorferJuan C García-Pagán
Jul 5, 2021·Acta Gastro-enterologica Belgica·A Galante, A De Gottardi
Aug 25, 2021·Hepatobiliary & Pancreatic Diseases International : HBPD INT·Martin BrichardLaurent Coubeau
Sep 29, 2021·Gastroenterology·Nicolas M IntagliataJonathan G Stine
May 2, 2020·Transfusion Medicine and Hemotherapy : Offizielles Organ Der Deutschen Gesellschaft Fur̈ Transfusionsmedizin Und Immunham̈atologie·Linfeng WuChunbao Guo

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Hepatology : Official Journal of the American Association for the Study of Liver Diseases
Sith SiramolpiwatJuan Carlos Garcia-Pagán
Nederlands tijdschrift voor geneeskunde
G P van Berge Henegouwen, K H Brandt
Annals of Hepatology
María Del Carmen Manzano-RobledaNahum Méndez-Sánchez
© 2022 Meta ULC. All rights reserved