Natural history of cardiac arrest in patients with takotsubo cardiomyopathy

The American Journal of Cardiology
Kuljit SinghMichel Le May

Abstract

Cardiac arrest (CA) is relatively rare but lethal complication of takotsubo cardiomyopathy (TTC). In most instances, patients are diagnosed with TTC after CA, making it difficult to distinguish if TTC is the precipitant or the consequence of the index event. In this systematic review, patient-level data were obtained to seek out the characteristics of patients in whom the underlying cause of CA is TTC. A comprehensive search of 4 major databases (Embase, Ovid MEDLINE, PubMed, and Google Scholar) was performed from their inception to the last week of September 2014. Of 186 citations, 62 case studies were included in the analysis, providing patient-level data on 77 patients. In 60 patients (78%), the diagnosis of TTC was made after CA. Patients presenting with CA were younger (mean age 49.5 ± 16 vs 64.9 ± 11 years, p <0.0001) and had relatively shorter corrected QT interval (mean 530 ± 101 vs 616 ± 140 ms) on electrocardiography. TTC-related hypotension was the major cause of CA in the acute phase, while a long corrected QT interval triggered CA in the subacute (24- to 72-hour) phase. In 11 patients, CA was not directly instigated by TTC despite a left ventricular appearance matching TTC. In conclusion, in TTC, CA typically devel...Continue Reading

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Citations

May 24, 2015·The American Journal of Cardiology·Paolo Angelini, Carlo Uribe
May 6, 2015·The American Journal of Cardiology·Kuljit SinghBjörn Redfors
May 10, 2015·The American Journal of Cardiology·John E Madias
Apr 8, 2016·The Korean Journal of Internal Medicine·Jung-Hee LeeMoon-Hyoung Lee
Jun 22, 2016·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·Eugene A Hessel
May 18, 2019·European Heart Journal·Sebastiano GiliChristian Templin
May 23, 2019·European Heart Journal·Ilan S Wittstein

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