Natural History of Diabetic Coronary Atherosclerosis by Quantitative Measurement of Serial Coronary Computed Tomographic Angiography: Results of the PARADIGM Study

JACC. Cardiovascular Imaging
Ung KimHyuk-Jae Chang

Abstract

This study aimed to determine the rate and extent of plaque progression (PP), changes in plaque features, and clinical predictors of PP in patients with diabetes mellitus (DM). The natural history of coronary PP in patients with DM is not well established. A total of 1,602 patients (age 61.3 ± 9.0 years; 60.3% men; median scan interval 3.8 years) who underwent serial coronary computed tomography angiography over a period of at least 24 months were enrolled and analyzed from the PARADIGM (Progression of Atherosclerotic Plaque Determined by Computed Tomographic Angiography Imaging) trial. Study endpoints were changes in plaque features in diabetics with PP and risk factors for PP by serial coronary computed tomography angiography between patients with and without DM. PP was defined if plaque volume at follow-up minus plaque volume at baseline was >0. DM was an independent risk factor for PP (84.6%; 276 of 326 patients with PP) in multivariate analysis (odds ratio [OR]: 1.526; 95% confidence interval [CI]: 1.100 to 2.118; p = 0.011). Independent risk factors for PP in patients with DM were male sex (OR: 1.485; 95% CI: 1.003 to 2.199; p = 0.048) and mean plaque burden at baseline ≥75% (OR: 3.121; 95% CI: 1.701 to 5.725; p ≤0.001). ...Continue Reading

Citations

Aug 15, 2019·European Heart Journal Cardiovascular Imaging·Seokhun YangHyuk-Jae Chang
Mar 3, 2020·Annual Review of Biomedical Engineering·Michael SturekFrank W Sellke
Sep 13, 2019·Arteriosclerosis, Thrombosis, and Vascular Biology·Evangelos K OikonomouCharalambos Antoniades
May 28, 2020·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·Guillermo Romero-FarinaJaume Candell-Riera
Mar 3, 2020·Frontiers in Cardiovascular Medicine·Jenny E KanterKarin E Bornfeldt
Aug 20, 2019·JACC. Cardiovascular Imaging·Daniele AndreiniUNKNOWN CAPIRE Investigators
Jan 17, 2021·Journal of Cardiovascular Computed Tomography·Alexander R van RosendaelHyuk-Jae Chang
May 25, 2021·The International Journal of Cardiovascular Imaging·Zhao-Qian WangChong-Fu Jia
Jun 3, 2021·Journal of Clinical Medicine·Marjorie CanuGilles Barone-Rochette
Jun 16, 2021·Open Heart·Rami M AbazidWilliam C Vezina
Sep 12, 2020·JACC. Cardiovascular Imaging·Leslee J ShawY Chandrashekar
Nov 11, 2021·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·Donghee HanPiotr J Slomka

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