Natural History of Drusenoid Pigment Epithelial Detachment Associated with Age-Related Macular Degeneration: Age-Related Eye Disease Study 2 Report No. 17

Ophthalmology
Jeannette J YuAge-Related Eye Disease Study 2 Research Group

Abstract

To investigate the natural history and genetic associations of drusenoid pigment epithelial detachment (DPED) associated with age-related macular degeneration (AMD). Retrospective analysis of a prospective cohort study. Of the 4203 Age-Related Eye Disease Study 2 (AREDS2) participants, 391 eyes (325 participants) had DPED without late AMD at the time of DPED detection. Genetic analyses included 120 white AREDS2 participants and 145 Age-Related Eye Disease Study (AREDS) participants with DPED. Baseline and annual stereoscopic fundus photographs were graded centrally to detect DPED, a well-defined yellow elevated mound of confluent drusen ≥433 μm in diameter, and to evaluate progression rates to late AMD: geographic atrophy (GA) and neovascular (NV)-AMD. Five single nucleotide polymorphisms (CFH [rs10611670], C3 [rs2230199], CFI [rs10033900], C2/CFB [rs114254831], ARMS2 [rs10490924]) and genetic risk score (GRS) group were investigated for association with DPED development. Kaplan-Meier analyses and multivariable proportional hazard regressions were performed. Progression rates to late AMD and decrease of ≥3 lines in visual acuity (VA) from the time of DPED detection; association of rate of DPED development with genotype. Mean (s...Continue Reading

Citations

Oct 4, 2020·Annals of Work Exposures and Health·Mattias A S HenningKristina S Ibler
Sep 4, 2020·Vestnik oftalmologii·M V BudzinskayaA O Tarasenkov
Apr 12, 2020·American Journal of Ophthalmology·Ursula Schmidt-ErfurthGregor S Reiter
May 20, 2020·Survey of Ophthalmology·Kai Xiong CheongGemmy Chui Ming Cheung
May 1, 2021·International Journal of Molecular Sciences·Taiyo ShijoKenji Kashiwagi
Mar 17, 2020·Ophthalmologica. Journal international d'ophtalmologie. International journal of ophthalmology. Zeitschrift für Augenheilkunde·Vasilena SitnilskaSascha Fauser

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