Natural history of fetal trisomy 18 after prenatal diagnosis

Archives of Disease in Childhood. Fetal and Neonatal Edition
Annette L BurkeJohn J Morrison

Abstract

To evaluate the natural fetal and neonatal outcome for pregnancies with an established prenatal diagnosis of fetal trisomy 18, and a parental decision for continuation of the pregnancy. The obstetric and neonatal outcome data for 23 such pregnancies, diagnosed at a single referral Fetal Medicine Centre, were retrospectively obtained. The overall intrauterine fetal death rate was 61%, with a progressive decline in live fetuses up to 39 weeks gestation. For fetuses diagnosed before 20 weeks gestation, there was a trend towards a higher intrauterine fetal death rate (88%), in comparison to those diagnosed after this period (44%) (p=0.06). For live births, the preterm delivery rate was 44%. All infants born alive died within 48 h of birth. These data provide reliable information for parental counselling pertaining to risk of intrauterine death when trisomy 18 is diagnosed prenatally. These findings suggest that long-term survival implications for trisomy 18 are different when it is diagnosed prenatally.

Citations

Oct 17, 2015·American Journal of Medical Genetics. Part a·Francesca M RussoPatrizia Vergani
Sep 10, 2014·Seminars in Fetal & Neonatal Medicine·Dominic WilkinsonVicki Xafis
Mar 31, 2015·Advances in Neonatal Care : Official Journal of the National Association of Neonatal Nurses·Maria-Eulàlia Juvé-UdinaSergio Alonso-Fernandez
May 18, 2016·Obstetrical & Gynecological Survey·Sarah K Dotters-KatzRobert A Strauss
Oct 27, 2016·Revista chilena de pediatría·Rosa A Pardo VargasSilvia Castillo Taucher
May 12, 2016·Revista da Associação Médica Brasileira·Vanessa Vigna GoulartMarcelo Zugaib
Oct 24, 2014·American Journal of Medical Genetics. Part a·Sinead C BarryJohn J Morrison
Jan 1, 2014·American Journal of Medical Genetics. Part a·Deborah Bruns, Emily Campbell
Feb 17, 2018·Archives of Disease in Childhood·Hannah SpiersonNgozi Edi-Osagie
Mar 23, 2017·American Journal of Medical Genetics. Part a·Alana Cavadino, Joan K Morris
Feb 12, 2017·The Journal of Medical Humanities·Megan J Thorvilson, Adam J Copeland
Jan 8, 2016·American Journal of Medical Genetics. Part a·Joan K Morris
Oct 21, 2020·Prenatal Diagnosis·Howard Cuckle, Joan Morris
Jul 4, 2021·Journal of Community Genetics·Emer GunneDeborah M Lambert

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