Natural history of growth and body composition in juvenile idiopathic arthritis

Hormone Research
S Bechtold, Johannes Roth

Abstract

In patients with juvenile idiopathic arthritis (JIA), growth impairment and altered body composition, including disturbed skeletal development, are well-known long-term complications. Data on longitudinal growth in patients with systemic and polyarticular JIA reveal growth impairment in the active phases of the disease. With reduction in disease activity and lower glucocorticoid (GC) doses, some patients experience 'catch-up' growth; however, many have only a slight improvement in height standard deviation during puberty or after cessation of GC treatment. The consequence is a final height below the 3rd percentile and below the genetic height potential. Although few studies have specifically addressed body composition in children with JIA, studies on the development of bone mass have described notable deficits in both GC-treated and GC-naïve children. In recent years, the deficits in bone mass have been related, in part, to the deficits in muscle mass, which are prevalent in these patients. The major goal for physicians caring for patients with JIA is optimal disease control while maintaining normal growth. Early recognition of patients who develop prolonged growth disturbances and altered body composition is important as these...Continue Reading

Citations

Dec 1, 2011·The Angle Orthodontist·Ahmet Yalcin GungorMurat Tutanc
Apr 17, 2014·Indian Pediatrics·Rakesh MondalSushas Ganguli
Mar 1, 2012·Clinical Rheumatology·Michelle Cavalcante CaetanoMaria Odete Hilário
Jul 24, 2012·Rheumatic Diseases Clinics of North America·Katherine Anne B Marzan, Bracha Shaham
Apr 4, 2015·BioMed Research International·Ewa Jednacz, Lidia Rutkowska-Sak
Feb 16, 2017·Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy·M A Maynez-RojasJ L Ruvalcaba-Sil
Apr 25, 2017·Hormone Research in Pædiatrics·Emelie Benyi, Lars Sävendahl
Apr 23, 2019·Special Care in Dentistry : Official Publication of the American Association of Hospital Dentists, the Academy of Dentistry for the Handicapped, and the American Society for Geriatric Dentistry·Angela Pia CazzollaLorenzo Lo Muzio
Apr 9, 2014·Journal of Molecular Endocrinology·Bettina SederquistLars Sävendahl
Jul 25, 2019·Pediatric Rheumatology Online Journal·Emmanuelle RochetteEtienne Merlin
Jan 13, 2018·Pediatric Annals·Armin ValdesHector Granados
Jan 10, 2019·Journal of Immunology Research·Anna-Carin LundellRille Pullerits
Oct 19, 2017·Experimental and Therapeutic Medicine·Myung-Gyou KimKang-Hyun Leem

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