Natural history of node-positive breast cancer: the curability of small cancers with a limited number of positive nodes

Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology
C A QuietS Hellman

Abstract

The long-term outcome of node-positive breast cancer was analyzed to determine the risk of metastatic disease as a function of tumor size and number of positive nodes. From 1927 to 1987, 501 women with node-positive breast cancer were treated at the University of Chicago Medical Center. Patients were treated with radical, extended radical, or modified radical mastectomy. Forty-eight patients received multiagent chemotherapy, and 118 were treated with hormonal therapy. The mean survival duration is 120 months, with a maximal follow-up time of 485 months (40 years). The number of nodes that contained metastatic disease and the pathologic size of the primary tumor were significant determinants of disease-free-survival (DFS) by multivariate analysis (P < .001). In patients with fewer than four positive nodes, tumor size was of prognostic importance, with small tumors more likely to be cured by local-regional therapy. The 20-year DFS rate for patients with one positive node was 69%; however, if the primary tumor was < or = 2 cm, the 20-year DFS rate was 81%, compared with 59% if the tumor was larger than 2 cm. Patients with two or three positive nodes had a 73% 20-year DFS rate if the tumor size was < or = 2 cm, compared with 53% 20...Continue Reading

Citations

Apr 14, 2000·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·M ExtermannG H Lyman
Feb 2, 2000·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·R Heimann, S Hellman
Sep 5, 2002·Cancer·James S MichaelsonKevin Hughes
Dec 1, 2007·Biomarkers in Medicine·Andrea NicoliniPaolo Miccoli
May 30, 2013·American Society of Clinical Oncology Educational Book·Kathrin Strasser-Weippl, Paul E Goss
Mar 6, 1999·Breast Cancer Research and Treatment·D L PageJ F Simpson
Mar 5, 1999·Breast Cancer Research and Treatment·R HeimannS Hellman
Oct 2, 1997·The New England Journal of Medicine·S Hellman
May 20, 1999·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·G ParmigianiL R Prosnitz
Jan 25, 2006·The Breast Journal·Roman ShyyanUNKNOWN Global Summit Diagnosis and Pathology Panel
Jul 23, 2005·Journal of Investigative Surgery : the Official Journal of the Academy of Surgical Research·Abut KebudiAygün Yildiz
Oct 21, 2009·Journal of Cellular and Molecular Medicine·Yi PengPeng Lee
Oct 4, 2017·Southern Medical Journal·Susmitha Apuri
Nov 2, 2005·Breast Cancer Research and Treatment·Arash Naeim, Emmett B Keeler
Feb 25, 1999·Annals of Surgical Oncology·M Morrow
Jun 15, 1997·Cancer·S Hellman
Nov 6, 2003·Cancer·James S MichaelsonBarbara Smith
Nov 27, 1998·Annals of Surgical Oncology·V Velanovich, W Szymanski
Nov 23, 2020·British Journal of Anaesthesia·Giacomo MontagnaJoshua S Mincer
Feb 1, 2003·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Jenny HuangWilliam J Mackillop

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