Natural history of Rathke's cleft cysts: A retrospective analysis of a two centres experience

Clinical Endocrinology
Elisa SalaLaurence Katznelson

Abstract

Rathke's cleft cyst (RCC) is a common sellar lesion which may cause visual impairment, hypopituitarism and headaches from mass effect. The natural history of these lesions is currently unclear. We investigated the natural history of RCCs and compared surgically treated patients with those treated conservatively. We performed a retrospective cohort study of patients diagnosed with a RCC between 1996 and 2016 at Stanford University and Ospedale Maggiore Policlinico di Milano. Patients were divided into 2 cohorts: Group A, 72 subjects who underwent surgical resection of a symptomatic RCC, and Group B, 62 subjects managed conservatively. Compared to Group B, Group A subjects had larger RCCs (79% vs 22% had a largest diameter >10 mm, P < .001) and were more likely (41.5% vs 16%, P < .001) to present with hypopituitarism and diabetes insipidus (DI) (18% vs 1.6%, P = .002). In Group A, after a mean follow-up of 53.7 months, 12.5% of patients had recurrence and a second surgery. After surgery, 35% of patients recovered pituitary function. Hyperprolactinemia (26.6%) and hypogonadism (66.6%) resolved more commonly that did DI (20.1%). New pituitary deficits appeared in 16.6% of patients after surgery. In Group B, with a mean follow-up of...Continue Reading

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Citations

Mar 14, 2019·The Journal of Craniofacial Surgery·Binghong ChenYongming Qiu
Jan 17, 2020·Neurosurgery·Pankaj K AgarwallaBrooke Swearingen
Jul 14, 2019·The Journal of Craniofacial Surgery·Binghong ChenYongming Qiu
Jan 16, 2021·Neuro-Chirurgie·L U F TruongC F Litré
Mar 27, 2021·Journal of Neuroendocrinology·Anna AngelousiGregory Kaltsas
Oct 2, 2021·Radiographics : a Review Publication of the Radiological Society of North America, Inc·Robert Y ShihKelly K Koeller

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