Natural History of Unruptured Intracranial Aneurysms : A Retrospective Single Center Analysis

Journal of Korean Neurosurgical Society
Hyoung Soo ByounO-Ki Kwon

Abstract

We conducted a retrospective cohort study to elucidate the natural course of unruptured intracranial aneurysms (UIAs) at a single institution. Data from patients diagnosed with UIA from March 2000 to May 2008 at our hospital were subjected to a retrospective analysis. The cumulative and annual aneurysm rupture rates were calculated. Additionally, risk factors associated with aneurysmal rupture were identified. A total of 1339 aneurysms in 1006 patients met the inclusion criteria. During the follow-up period, 685 aneurysms were treated before rupture via either an open surgical or endovascular procedure. Six hundred fifty-four UIAs were identified and not repaired during the follow-up period. The mean UIA size was 4.5±3.2 mm, and 86.5% of the total UIAs had a largest dimension <7 mm. Among these UIAs, 18 ruptured at a median of 1.6 years (range : 27 days to 9.8 years) after day 0. The annual rupture risk during a 9-year follow-up was 1.00%. A multivariate Cox proportional hazards analysis revealed that the aneurysm size and a history of subarachnoid hemorrhage (SAH) were statistically significant risk factors for rupture. For an aneurysms smaller than 7 mm in the absence of a history of SAH, the annual rupture risk was 0.79%. In...Continue Reading

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Citations

Oct 28, 2017·Journal of Clinical Nursing·Mi-Sun LeeNahyun Kim
Nov 17, 2016·Journal of Cerebrovascular and Endovascular Neurosurgery·Siwoo LeeChang-Young Kweon
Jun 7, 2017·Annals of Internal Medicine·Ajay MalhotraPina Sanelli
Mar 10, 2019·Brain : a Journal of Neurology·Jae-Sik NamIn-Cheol Choi

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