Natural human antibodies to dietary lectins

FEBS Letters
B Tchernychev, M Wilchek

Abstract

Natural antibodies to self and non-self proteins, including dietary proteins, are a significant part of the immune repertoire of humans. Antibodies to three structurally related legume lectins (Erythrina corallodendron lectin (ECorL), peanut agglutinin (PNA), and soybean agglutinin (SBA)) and to one cereal lectin (wheat germ agglutinin (WGA)) were purified by affinity chromatography from human sera and their binding specificity examined. The anti-SBA, anti-ECorL and anti-WGA antibodies exhibited high specificity, whereas the anti-PNA antibodies were polyreactive. Although the anti-WGA antibodies were highly specific for WGA, they also crossreacted slightly toward some other proteins. The anti-ECorL antibodies bound to native SBA, but the anti-SBA antibodies failed to bind to the native ECorL. Although the anti-SBA and anti-ECorL antibodies both exhibited specificity when interacting with native lectins, they bound to a wider range of denatured lectins, indicating a common or universal epitope which is recognized by many natural antibodies. Interestingly, the natural antibodies did not interfere with the agglutination properties of the lectins. These findings may provide a basis for studying the in vivo biological effects of ant...Continue Reading

References

Apr 15, 1992·European Journal of Biochemistry·R ArangoN Sharon
Nov 1, 1990·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·N Sharon, H Lis
Feb 1, 1988·The Journal of Experimental Medicine·H J de Aizpurua, G J Russell-Jones
Jul 1, 1993·The British Journal of Nutrition·A PusztaiS Bardocz
Mar 1, 1993·Immunology Letters·M O BubbM Wilchek
Jan 1, 1995·Advances in Experimental Medicine and Biology·E GómezH Bourges

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Citations

Feb 19, 2004·Advanced Drug Delivery Reviews·Franz GaborMichael Wirth
Jul 17, 1999·International Journal of Immunopharmacology·A HaqS T Al-Sedairy
Oct 29, 2002·International Immunopharmacology·Roberto ChignolaGiancarlo Andrighetto
May 12, 2001·The British Journal of Nutrition·B WatzlB L Pool-Zobel
Dec 13, 2005·BMC Endocrine Disorders·Tommy JönssonStaffan Lindeberg
Mar 14, 2013·Nutrients·Karin de Punder, Leo Pruimboom
Jun 10, 1997·Proceedings of the National Academy of Sciences of the United States of America·B TchernychevM Wilchek
Dec 3, 2013·Comparative Biochemistry and Physiology. Part A, Molecular & Integrative Physiology·Anne Marie BakkeÅshild Krogdahl
Jul 10, 2010·International Immunopharmacology·Fatima Clement, Yeldur P Venkatesh
Jun 26, 2010·Medicinal Research Reviews·K O François, J Balzarini
Aug 11, 2004·Toxicon : Official Journal of the International Society on Toxinology·Ilka M Vasconcelos, José Tadeu A Oliveira
Jan 15, 2017·The Journal of Immunology : Official Journal of the American Association of Immunologists·Tao GongWei Jiang
Apr 2, 2020·Frontiers in Immunology·Matías L GiglioHoracio Heras
Feb 28, 2020·Journal of Immunology Research·Aristo VojdaniElroy Vojdani
Dec 17, 2020·Nutrients·Maria Gloria MumoloMassimo Bellini
Feb 11, 2021·Foods·Luis E Rojas Tovar, Michael G Gänzle

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