Natural human humoral response to salivary gland proteins of Anopheles mosquitoes in Thailand

Acta Tropica
Amornrat WaitayakulRachanee Udomsangpetch

Abstract

During blood feeding, arthropod vectors inject saliva into vertebrate hosts. The saliva is biochemically complex and pharmacologically active, and may play an important role in pathogen transmission. To examine whether mosquito saliva could elicit humoral immune response in humans under natural conditions, we have collected sera from malaria patients, healthy villagers, and people from a non-malarious region in Thailand. Here we have demonstrated that anti-Anopheles salivary protein antibodies occurred predominantly in patients with acute Plasmodium falciparum or P. vivax malaria, whereas people from a non-malarious area had no such antibodies. Besides, antibody levels against mosquito salivary proteins in malaria patients were highly variable, which may be related to the levels of mosquito exposure. Despite variability, patients' sera with high IgG titers consistently detected several proteins in Anopheles dirus salivary gland protein extracts. Immunohistochemical staining of Anopheles salivary glands with human sera showed that the salivary gland-specific IgGs reacted strongly with the median lobe. Comparison using Anopheles and Aedes salivary proteins suggests that the anti-salivary protein antibodies detected in malaria pat...Continue Reading

References

Aug 20, 1976·Science·W Trager, J B Jensen
Jan 1, 1990·Medical and Veterinary Entomology·M S RamasamyR Ramasamy
Jan 1, 1990·International Archives of Allergy and Applied Immunology·H Brummer-KorvenkontioT Palosuo
Jan 1, 1987·Annual Review of Entomology·J M Ribeiro
Oct 1, 1995·Medical and Veterinary Entomology·K A SrikrishnarajM S Ramasamy
Feb 1, 1997·International Archives of Allergy and Immunology·H Brummer-KorvenkontioT Reunala
Nov 5, 1997·The American Journal of Tropical Medicine and Hygiene·S Sidjanski, J P Vanderberg
Jan 28, 1998·Annual Review of Entomology·J C Beier
Apr 12, 2000·Parasite Immunology·V HajnickáP A Nuttall
Jul 18, 2000·Transactions of the Royal Society of Tropical Medicine and Hygiene·S I HayR W Snow
Nov 23, 2000·Proceedings of the National Academy of Sciences of the United States of America·J D BrennanN Kumar
Sep 20, 2001·The American Journal of Tropical Medicine and Hygiene·S Owusu-AgyeiS L Hoffman
Jan 31, 2002·Transactions of the Royal Society of Tropical Medicine and Hygiene·K ChotivanichN J White
Feb 8, 2002·Nature·Brian Greenwood, Theonest Mutabingwa
Aug 27, 2002·Annual Review of Entomology·Jose M C Ribeiro, Ivo M B Francischetti
Jun 27, 2003·Insect Biochemistry and Molecular Biology·Jesus G ValenzuelaJosé M C Ribeiro
Jan 20, 2004·Insect Molecular Biology·E CalvoO Marinotti
Feb 14, 2004·International Archives of Allergy and Immunology·Zhikang Peng, F Estelle R Simons
Apr 6, 2004·Journal of Medical Entomology·Russell E ColemanJetsumon Sattabongkot
Aug 12, 2004·Tropical Medicine & International Health : TM & IH·Denise Njama-MeyaGrant Dorsey
May 1, 1990·Parasitology Today·R G Titus, J M Ribeiro
Jan 18, 2005·Memórias do Instituto Oswaldo Cruz·Ana C V M da RochaPaulo F P Pimenta

❮ Previous
Next ❯

Citations

Oct 4, 2011·The Journal of Biological Chemistry·Jonas G KingJulián F Hillyer
Nov 15, 2012·BMC Genomics·Albin FontaineLionel Almeras
Apr 19, 2011·Malaria Journal·Lena Hulden, Larry Hulden
Jun 7, 2007·Malaria Journal·Sylvie CornelieFrancois Simondon
Aug 1, 2012·The American Journal of Tropical Medicine and Hygiene·Souleymane DoucoureFranck Remoue
Oct 22, 2013·Journal of Proteomics·José M BautistaAntonio Puyet
Nov 26, 2015·Insects·Souleymane Doucoure, Papa Makhtar Drame
May 16, 2009·Insect Biochemistry and Molecular Biology·Fabrizio LombardoBruno Arcà
Jun 10, 2015·Journal of Infection and Public Health·Rike OktariantiAulanni'am
Aug 28, 2015·Revista Da Sociedade Brasileira De Medicina Tropical·Yunita ArmiyantiTeguh Wahju Sardjono
Sep 9, 2011·Memórias do Instituto Oswaldo Cruz·Bruno Bezerril Andrade, Manoel Barral-Netto
Jul 22, 2015·The American Journal of Tropical Medicine and Hygiene·Berlin Londono-RenteriaSteven R Meshnick
May 25, 2016·Infection and Immunity·Zachary P BillmanSean C Murphy
Aug 2, 2019·Experimental & Applied Acarology·José Francisco Lima-BarberoJosé de la Fuente
Sep 29, 2020·Frontiers in Cellular and Infection Microbiology·Berlin Londono-RenteriaAudrey E Lenhart
Oct 3, 2018·Tropical Medicine and Infectious Disease·André B SagnaFranck Remoue

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antimalarial Agents

Antimalarial agents, also known as antimalarials, are designed to prevent or cure malaria. Discover the latest research on antimalarial agents here.

Antimalarial Agents (ASM)

Antimalarial agents, also known as antimalarials, are designed to prevent or cure malaria. Discover the latest research on antimalarial agents here.

© 2021 Meta ULC. All rights reserved