Natural hydrogels R&D process: technical and regulatory aspects for industrial implementation.

Journal of Materials Science. Materials in Medicine
Marta Calvo CatoiraFrancesca Boccafoschi

Abstract

Since hydrogel therapies have been introduced into clinic treatment procedures, the biomedical industry has to face the technology transfer and the scale-up of the processes. This will be key in the roadmap of the new technology implementation. Transfer technology and scale-up are already known for some applications but other applications, such as 3D printing, are still challenging. Decellularized tissues offer a lot of advantages when compared to other natural gels, for example they display enhanced biological properties, due to their ability to preserve natural molecules. For this reason, even though their use as a source for bioinks represents a challenge for the scale-up process, it is very important to consider the advantages that originate with overcoming this challenge. Therefore, many aspects that influence the scaling of the industrial process should be considered, like the addition of drugs or cells to the hydrogel, also, the gelling process is important to determine the chemical and physical parameters that must be controlled in order to guarantee a successful process. Legal aspects are also crucial when carrying out the scale-up of the process since they determine the industrial implementation success from the regul...Continue Reading

References

Oct 1, 1992·Current Opinion in Cell Biology·T N WightE E Qwarnström
Jun 7, 2000·Journal of Biomaterials Science. Polymer Edition·A J KuijpersJ Feijen
Jun 28, 2001·Biomaterials·W F DaamenT H Van Kuppevelt
Aug 4, 2001·Molecular and Cellular Biology·M G Vander HeidenC B Thompson
Feb 9, 2002·Science·Linda G Griffith, Gail Naughton
Nov 5, 2003·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·Myung-Seob KhilNarayan Bhattarai
Jan 20, 2004·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Eve Ruel-GariépyJean-Christophe Leroux
Jan 10, 2006·Journal of Biomedical Materials Research. Part a·Ling ZhangXiufang Zhang
Apr 6, 2006·Journal of Biomedical Materials Research. Part a·Hisayo YamaokaKazuto Hoshi
Dec 1, 2006·Journal of Materials Science. Materials in Medicine·S A AbbahK D K Luk
Oct 22, 2008·Acta Biomaterialia·Scott A ZawkoChristine E Schmidt
Mar 28, 2009·Journal of the Royal Society, Interface·Yasuhiko Tabata
Jun 12, 2010·Biomaterials·Ross J DeVolder, Hyun-Joon Kong
Oct 6, 2010·Canadian Journal of Physiology and Pharmacology·Divya Pankajakshan, Devendra K Agrawal
Jan 26, 2011·Biotechnology Advances·R JayakumarH Tamura
Sep 10, 2011·Tissue Engineering. Part a·Christiane L SalgadoPedro L Granja
Jun 5, 2012·Journal of the Mechanical Behavior of Biomedical Materials·Daniel G T Strange, Michelle L Oyen
Jun 26, 2012·Advanced Drug Delivery Reviews·Elliott GruskinJeffrey O Hollinger
Sep 4, 2012·Journal of Biomedical Materials Research. Part a·Sean V MurphyAnthony Atala
Oct 30, 2012·Tissue Engineering. Part C, Methods·Mohammad A AlameinPatrick H Warnke
Dec 27, 2012·IEEE Reviews in Biomedical Engineering·Pinar ZorlutunaAli Khademhosseini
Apr 10, 2013·Journal of the Mechanical Behavior of Biomedical Materials·Khaow Tonsomboon, Michelle L Oyen
Mar 13, 2014·Langmuir : the ACS Journal of Surfaces and Colloids·S Connor DennisCory J Berkland
Sep 19, 2014·Journal of the Royal Society, Interface·Luca GasperiniRui L Reis
Mar 6, 2013·Advanced Functional Materials·Matthew J GlassmanBradley D Olsen
Jan 30, 2015·Vascular Health and Risk Management·Neelima Thottappillil, Prabha D Nair
Mar 10, 2015·Journal of Advanced Research·Enas M Ahmed
Mar 17, 2015·Biomedical Materials·Bobak MosadeghJames K Min
Dec 27, 2015·Materials Science & Engineering. C, Materials for Biological Applications·J Skopinska-WisniewskaM Ziegler-Borowska
Dec 5, 2016·Acta Biomaterialia·Lindsey T SaldinStephen F Badylak
Feb 15, 2017·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·Marek KaweckiAleksandra Kasperczyk
Mar 22, 2018·International Journal of Medical Sciences·Andrea PacificiLuciano Pacifici
Oct 9, 2018·Biotechnology Progress·Rajesh Guruswamy Damodaran, Patrick Vermette
Jan 27, 2019·Bioengineering & Translational Medicine·Yu Seon KimAntonios G Mikos
Jan 27, 2019·Bioengineering & Translational Medicine·Samson AfewerkiAli Khademhosseini
Mar 27, 2019·Tissue Engineering. Part C, Methods·Mollie M SmoakAntonios G Mikos
Oct 11, 2019·Journal of Materials Science. Materials in Medicine·Marta Calvo CatoiraFrancesca Boccafoschi

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Citations

Mar 7, 2021·Polymers·Jose Maria AlonsoVirginia Saez-Martinez
Apr 4, 2021·Polymers·Emma Barrett-CattonPrashanth Asuri

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Methods Mentioned

BETA
bioprinting
rheology
bioprinter

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