PMID: 9420264Jan 7, 1998Paper

Natural infection of a household pet red-capped mangabey (Cercocebus torquatus torquatus) with a new simian immunodeficiency virus

Journal of Virology
M C Georges-CourbotP A Marx

Abstract

A seroprevalence survey was conducted for simian immunodeficiency virus (SIV) antibody in household pet monkeys in Gabon. Twenty-nine monkeys representing seven species were analyzed. By using human immunodeficiency virus type 2 (HIV-2)/SIVsm, SIVmnd, and SIVagm antigens, one red-capped mangabey (RCM) (Cercocebus torquatus torquatus) was identified as harboring SIV-cross-reactive antibodies. A virus isolate, termed SIVrcm, was subsequently established from this seropositive RCM by cocultivation of its peripheral blood mononuclear cells (PBMC) with PBMC from seronegative humans or RCMs. SIVrcm was also isolated by cocultivation of CD8-depleted RCM PBMC with Molt 4 clone 8 cells but not with CEMx174 cells. The lack of growth in CEMx174 cells distinguished this new SIV from all previously reported sooty mangabey-derived viruses (SIVsm), which grow well in this cell line. SIVrcm was also successfully transmitted (cell free) to human and rhesus PBMC as well as to Molt 4 clone 8 cells. To determine the evolutionary origins of this newly identified virus, subgenomic pol (475 bp) and gag (954 bp) gene fragments were amplified from infected cell culture DNA and sequenced. The position of SIVrcm relative to those of members of the other ...Continue Reading

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Citations

Jun 30, 2000·AIDS Research and Human Retroviruses·J YamaguchiC A Brennan
Jun 19, 2001·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·P A MarxE Drucker
Jun 14, 2003·Molecular Ecology·P T TelferE J Wickings
Apr 16, 2004·Clinical Microbiology Reviews·Malavika GiriDavid B Weiner
Jan 14, 2004·The Journal of General Virology·Ernst J VerschoorJonathan L Heeney
Feb 26, 2004·American Journal of Primatology·Lisa Jones-EngelRandall C Kyes
Jul 10, 2004·AIDS Research and Human Retroviruses·Maria MakuwaPierre Roques
Jul 4, 2001·Journal of Virology·S SouquièreF Simon
Sep 25, 1998·Journal of Medical Primatology·S M SmithP A Marx
Mar 18, 2003·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Tobias A GrimmKathleen A Clouse
Apr 9, 2005·Cell Death and Differentiation·B HurtrelJ Estaquier
Mar 16, 2006·Journal of Virology·Richard OnangaPierre Roques
Jun 14, 2003·Journal of Virology·Marco SalemiAnne-Mieke Vandamme
Oct 14, 2004·Journal of Virology·Nathan C GaddisMichael H Malim
Oct 17, 2006·Clinical Microbiology Reviews·Sue VandeWoude, Cristian Apetrei
May 9, 2002·Emerging Infectious Diseases·Martine PeetersEric Delaporte
Mar 27, 2002·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Jason T BlackardKenneth H Mayer

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