PMID: 9557685Apr 29, 1998Paper

Natural isolates of simian virus 40 from immunocompromised monkeys display extensive genetic heterogeneity: new implications for polyomavirus disease

Journal of Virology
John A LednickyJanet S Butel

Abstract

Simian virus 40 (SV40) DNAs in brain tissue and peripheral blood mononuclear cells (PBMCs) of eight simian immunodeficiency virus-infected rhesus monkeys with SV40 brain disease were analyzed. We report the detection, cloning, and identification of five new SV40 strains following a quadruple testing-verification strategy. SV40 genomes with archetypal regulatory regions (containing a duplication within the G/C-rich regulatory region segment and a single 72-bp enhancer element) were recovered from seven animal brains, two tissues of which also contained viral genomes with nonarchetypal regulatory regions (containing a duplication within the G/C-rich regulatory region segment as well as a variable duplication within the enhancer region). In contrast, PBMC DNAs from five of six animals had viral genomes with both regulatory region types. It appeared, based on T-antigen variable-region sequences, that nonarchetypal virus variants arose de novo within each animal. The eighth animal exclusively yielded a new type of SV40 strain (SV40-K661), containing a protoarchetypal regulatory region (lacking a duplication within the G/C-rich segment of the regulatory region and containing one 72-bp element in the enhancer region), from both brain ...Continue Reading

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Citations

Jul 20, 2004·Clinical Microbiology Reviews·Regis A Vilchez, Janet S Butel
Sep 28, 2005·The Journal of General Virology·Shaojie ZhangJanet S Butel
Aug 24, 2007·Journal of Virology·Reimar Johne, Hermann Müller
Nov 6, 2007·Journal of Virology·Vojtech SrollerJanet S Butel
Dec 28, 2002·Journal of Virology·Riccardo DolcettiMauro Tognon
Sep 28, 2006·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Regis A Vilchez, Shimon Kusne
Feb 8, 2002·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Regis A VilchezJanet S Butel
Oct 18, 2002·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Eun Jeong KwakShimon Kusne
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Jul 24, 2008·Journal of Neuropathology and Experimental Neurology·Xin DangIgor J Koralnik
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Aug 9, 2013·Journal of Virology·Chun Jung ChenChristopher S Sullivan
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Jul 11, 2007·Infectious Agents and Cancer·Fernanda MartiniMauro Tognon

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