PMID: 8400669Jan 1, 1993Paper

Natural killer activity and serum immunosuppressive acidic protein levels in esophageal and gastric cancers

Surgery Today
M OkaT Suzuki

Abstract

The natural killer (NK) activity of peripheral blood mononuclear cells and serum immunosuppressive acidic protein (IAP) levels were examined in patients with esophageal or gastric cancer, before and after surgery. Patients with stage IV esophageal or stage IV gastric cancer had significantly lower NK activity (39.5 +/- 14.8% and 37 +/- 11.6%, respectively), and also higher serum IAP levels (778 +/- 264 micrograms/mL and 633 +/- 156 micrograms/mL, respectively), than the corresponding control values (50 +/- 5.6% and 375 +/- 26 micrograms/mL, respectively). Patients with esophageal or gastric cancer who underwent curative resection had high NK activity (54.8 +/- 11.6% and 54.8 +/- 8.0%, respectively), and low IAP levels (471 +/- 116 micrograms/mL and 490 +/- 42 micrograms/mL, respectively), compared with those who underwent non-curative resection. Patients who underwent non-curative resection had lower NK activity and higher serum IAP levels than those who underwent curative resection, even 1 month after surgery. Mononuclear cells in the regional lymph nodes and tumor specimens showed significantly lower NK activity than those in the peripheral blood and spleen. Thus, NK activity and the IAP level reflected the immunocompetence, ...Continue Reading

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Citations

Jul 1, 1995·Digestive Diseases and Sciences·J A VargasA Durántez
Jun 1, 2011·Gastric Cancer : Official Journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association·Hiroaki SaitoMasahide Ikeguchi
Nov 28, 2012·Gastric Cancer : Official Journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association·Hiroaki SaitoMasahide Ikeguchi
Jun 1, 2005·Cancer Treatment Reviews·Joseph M KaminskiJeffrey Brousal
Nov 1, 1995·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·M OkaT Suzuki
Feb 1, 2003·Analytical Sciences : the International Journal of the Japan Society for Analytical Chemistry·Koji HigaiKojiro Matsumoto
Sep 17, 2013·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·Jing QuJian Zhang
Feb 14, 2004·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·M A A Al-RawiW G Jiang
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Mar 10, 2001·The American Journal of Gastroenterology·H TakeuchiK Sugimachi
Apr 1, 2017·Experimental & Molecular Medicine·Hyung-Joon KwonHun Sik Kim

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