Abstract
Trypanosoma musculi infection affected natural killer (NK) activity in mice. In the spleen, an increase of two to three times normal was displayed on days 2 to 4 after inoculation of parasites, followed by rapid decline to a subnormal level of activity that persisted for more than 3 weeks and included the phase of rapid parasite elimination. NK activity increased dramatically in peritoneal exudate and marrow early in infection, but the subsequent decline was more moderate than in the spleen. The subnormal splenic activity was not elevated by treating infected mice with an interferon inducer, polyinosinic acid-polycytidylic acid. Serum interferon levels were elevated early in infection, but by day 4 postinoculation, they had returned to undetectable. Injection of mice with antiserum to murine interferon-beta did not inhibit the early rise in NK activity or alter the course of trypanosome infection; in fact, the antiserum treatment enhanced splenic NK activity in infected mice. The early rise and subsequent decline of NK activity did not correlate with the course of T. musculi infection and subsequent cure. The cause of the dramatic decline in splenic NK activity is under investigation; it could result, for example, from arousal ...Continue Reading
References
Aug 1, 1978·Proceedings of the National Academy of Sciences of the United States of America·J W AlbrightD G Dusanic
Jan 1, 1978·Advances in Cancer Research·R B Herberman, H T Holden
Jan 1, 1979·Immunological Reviews·G Cudkowicz, P S Hochman
Apr 1, 1978·Scandinavian Journal of Immunology·E Ojo, H Wigzell
Jun 29, 1978·Nature·M GidlundI Gresser
May 1, 1977·Infection and Immunity·R G RankW P Weidanz
Apr 1, 1975·International Journal for Parasitology·G A Targett, P Viens
Feb 1, 1975·European Journal of Immunology·R KiesslingH Wigzell
Apr 1, 1976·Infection and Immunity·R M Donahoe, K Y Huang
Jun 1, 1982·Infection and Immunity·R J Melder, M Ho
Oct 15, 1982·Science·F M Hatcher, R E Kuhn
May 15, 1982·Cellular Immunology·W E HauserJ S Remington
Dec 1, 1982·Mechanisms of Ageing and Development·J W Albright, J F Albright
Mar 1, 1981·Cellular Immunology·E M OpremcakR L Whisler
Jan 1, 1980·Parasite Immunology·E M Eugui, A C Allison
Aug 1, 1981·Infection and Immunity·J W Albright, J F Albright
Citations
Nov 13, 1984·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·B A Askonas, G J Bancroft
Jan 1, 1988·Transactions of the Royal Society of Tropical Medicine and Hygiene·P R RidelA Capron
Aug 1, 1994·Clinical and Experimental Immunology·A L SmithD Wakelin
Mar 15, 1997·Cellular Immunology·J W AlbrightJ F Albright
May 1, 1984·Infection and Immunity·J W AlbrightJ F Albright
Jan 1, 1985·Infection and Immunity·G MarquisP Auger
Apr 15, 1984·Cellular Immunology·C E Kirkpatrick, J P Farrell
Sep 1, 1984·Cellular Immunology·C E Kirkpatrick, J P Farrell