PMID: 6402457Mar 15, 1983Paper

Natural killer cell activity and spontaneous development of lymphoma. Effects of single and multiple injections of interferon into young and aged C57BL/6 mice

International Journal of Cancer. Journal International Du Cancer
M Bruley-Rosset, H Rappaport

Abstract

The capacity of interferon (IFN) given once or repeatedly to augment natural killer (NK) cell activity in the spleen was tested in young and aged C57BL/6 mice. Multiple injections of 10(4) u IFN i.p. into 3-month-old or 12-month-old mice did not augment cytotoxicity mediated by NK cell activity; rather it reduced this activity in relation to the effect obtained with a single injection. When T and B cells or macrophages were removed in vitro, no restoration of NK-cell activity, and therefore no suppressor cells, could be found in this system. In a long-term experiment, B6 mice were chronically injected with 10(4) u of IFN or mock-IFN from 5 months of age until death. No difference in the modification of NK-cell activity was observed after IFN and mock-IFN, regardless of the duration of treatment. However, the capacity of spleen cells to generate cytotoxic T cells after allogeneic stimulation in vitro or in vivo was increased in IFN-treated mice. The median survival time was improved by 7 weeks through treatment with IFN compared to mock-IFN, but was reduced by 9 weeks compared to the survival after treatment with saline. No significant difference in the incidence of spontaneous lymphoma resulted from IFN treatment, but the perce...Continue Reading

References

Jan 12, 1972·Nature: New Biology·J B HibbsJ S Remington
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