Natural killer cell activity is a risk factor for the recurrence risk after curative treatment of hepatocellular carcinoma.

BMC Gastroenterology
Han Ah LeeYeon Seok Seo

Abstract

Natural killer (NK) cells have been known to contribute to surveillance and control of hepatocellular carcinoma (HCC). However, the association of NK cell activity with stage and recurrence risk of HCC have not been fully evaluated. Untreated patients with newly diagnosed HCC were prospectively enrolled. Peripheral blood mononuclear cells were isolated at the time of diagnosis. Patients who had undergone surgery or radiofrequency ablation were classified as the curative treatment group, and their blood samples were collected again at 1 month after treatment. A total of 80 patients with HCC were enrolled. The mean age was 62.5 years. At baseline, interferon (IFN)-γ producing NK cell proportion was significantly lower in patients with Barcelona clinic liver cancer (BCLC) stage B, C, or D than in those with BCLC stage 0 (42.9% vs. 56.8%, P = 0.045). Among all patients, 56 patients had undergone curative treatment, and 42 patients re-visited at 1 month after curative treatment. There was no significant change in total NK cell and IFN-γ producing NK cell proportion from baseline to 1 month after treatment (all P > 0.05). During a median follow-up of 12.4 months, HCC recurred in 14 patients (33.3%). When patients were classified acco...Continue Reading

References

Nov 28, 2000·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Y KoikeM Omata
Jan 2, 2008·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Bin GaoZhigang Tian
Jul 25, 2008·Blood·Michael A Caligiuri
Oct 1, 2008·Clinical Immunology : the Official Journal of the Clinical Immunology Society·Lun CaiFu-Sheng Wang
Jun 25, 2009·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Bastian HoechstFirouzeh Korangy
Feb 9, 2010·Biochemical and Biophysical Research Communications·Omar DessoukiSeiji Okada
Feb 23, 2010·Seminars in Liver Disease·Riccardo Lencioni, Josep M Llovet
Jun 29, 2010·The Journal of Immunology : Official Journal of the American Association of Immunologists·Dong-Ming KuangLimin Zheng
Jan 12, 2011·Annual Review of Immunology·Matthew D VeselyMark J Smyth
Feb 15, 2011·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Kyu Sik JungKwang-Hyub Han
Mar 5, 2011·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Jordi BruixUNKNOWN American Association for the Study of Liver Diseases
Jul 21, 2011·Carcinogenesis·Cédric CoulouarnSnorri S Thorgeirsson
Dec 12, 2012·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Yan WuLimin Zheng
Jul 24, 2013·Journal of Gastroenterology and Hepatology·Hongyang Wang, Lei Chen
Aug 25, 2015·World Journal of Hepatology·Meenakshi SachdevaSunil K Arora
Dec 8, 2015·Cellular & Molecular Immunology·Hui PengZhigang Tian
Jan 9, 2018·Lancet·Alejandro FornerJordi Bruix
Jan 31, 2018·Nature Immunology·Marc RingelhanMathias Heikenwalder
Jun 7, 2018·NPJ Precision Oncology·Le-Xing YuHong-Yang Wang
Nov 23, 2018·International Journal of Molecular Sciences·Pil Soo Sung, Jeong Won Jang
Jan 22, 2019·Clinical and Molecular Hepatology·Yeun-Yoon KimMyeong-Jin Kim
Feb 15, 2019·Clinical and Molecular Hepatology·Tae-Hyung KimJeong Min Lee
Jul 5, 2019·Korean Journal of Radiology : Official Journal of the Korean Radiological Society·UNKNOWN Korean Liver Cancer Association (KLCA), UNKNOWN National Cancer Center (NCC), Goyang, Korea

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