Natural killer cell-based immunotherapy: From transplantation toward targeting cancer stem cells

Journal of Cellular Physiology
Hassan Dianat-MoghadamMehdi Yousefi

Abstract

Natural killer (NK) cells are key players of the innate immune system. NK cells provide protection against infectious pathogens and malignancies in cell. This characteristic may be attributable to their intrinsic diverse potentialities and also their cooperation with adaptive immune lymphocytes, known as B and T cells. The growth, recurrence, and metastasis of cancer cells, and the failure of cytoreductive therapies against cancer cells are due to the small population of intratumor stem-like cells, called cancer stem cells (CSCs). Furthermore, NK cells can efficiently eradicate heterogeneous tumor cells after a long-term treatment. Therefore, NK cell-based therapy is a promising strategy to target and break CSC-associated resistance to anticancer drugs treatment. In this review, we have presented an overview of the emerging knowledge of the characteristics, diversities, and mechanism-driven immune surveillance of human NK cells and advances in NK cell-based immunotherapies. Finally, we will discuss how these cells can be applied to introduce the next generation of vaccine- and immune-based approaches to prevent drug resistance.

References

Feb 5, 2000·The Journal of Immunology : Official Journal of the American Association of Immunologists·K TakedaK Okumura
Dec 14, 2002·Science·Nadia L BernasconiAntonio Lanzavecchia
Nov 24, 2004·The Journal of Immunology : Official Journal of the American Association of Immunologists·Jeroen van BergenFrits Koning
Apr 18, 2006·Current Opinion in Immunology·Rance E Berg, James Forman
Nov 15, 2006·Immunological Reviews·Aharon G Freud, Michael A Caligiuri
Apr 18, 2007·Nature Reviews. Immunology·Hans-Gustaf Ljunggren, Karl-Johan Malmberg
Mar 7, 2009·The Journal of Immunology : Official Journal of the American Association of Immunologists·Roberta CastriconiCristina Bottino
Jun 25, 2009·Expert Opinion on Investigational Drugs·Brett H YamanePaul M Sondel
Jul 21, 2009·Journal of Internal Medicine·T Sutlu, E Alici
Sep 10, 2009·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Jacquelyn A HankPaul M Sondel
Jan 5, 2010·MAbs·Mahendra P DeonarainAgamemnon A Epenetos
Jan 21, 2010·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Jeffrey E RubnitzWing Leung
May 5, 2011·Journal of Biomedicine & Biotechnology·Estrella Mariel LevyJosé Mordoh
Jun 11, 2011·Journal of Biomedicine & Biotechnology·Kory L Alderson, Paul M Sondel
Feb 23, 2012·The Journal of Clinical Investigation·Laure GineauEmmanuelle Jouanguy
Mar 23, 2012·Nature Reviews. Cancer·Drew M Pardoll
Sep 18, 2012·Blood·Rizwan RomeeTodd A Fehniger
Dec 5, 2012·The Journal of Experimental Medicine·Jing NiAdelheid Cerwenka
Apr 23, 2013·Cellular & Molecular Immunology·Min ChengZhigang Tian
Sep 18, 2013·The Journal of Experimental Medicine·Alexandre IannelloDavid H Raulet
Sep 24, 2013·Trends in Immunology·Jianhua YuMichael A Caligiuri
Apr 2, 2014·The Journal of Immunology : Official Journal of the American Association of Immunologists·Ana StojanovicAdelheid Cerwenka
Apr 9, 2014·Frontiers in Immunology·Leticia Huergo-ZapicoSegundo Gonzalez
Jul 6, 2014·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Wing Leung
Sep 26, 2014·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·Jonathan S BerekCarolyn N Krasner
Nov 19, 2014·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Kevin C ConlonThomas A Waldmann
Dec 17, 2014·Cancer Letters·Lakshmi Narendra BodduluruChandra Shaker Sriram
Dec 24, 2014·Cytotherapy·Hans Klingemann
Mar 7, 2015·Nature Reviews. Immunology·Ludovic Martinet, Mark J Smyth

❮ Previous
Next ❯

Citations

Dec 28, 2019·Scandinavian Journal of Immunology·Costanza Maria CristianiEnnio Carbone
Nov 7, 2019·Journal of Cellular Physiology·Navid ShomaliFaroogh Marofi
Aug 2, 2020·British Journal of Pharmacology·Pedro F PinheiroM Matilde Marques
Sep 25, 2019·Journal of Translational Medicine·Allison B PowellConrad Russell Y Cruz
Mar 17, 2020·Drug Delivery and Translational Research·Arpit BhargavaPradyumna Kumar Mishra
Aug 2, 2020·Life Sciences·Feifei Guo, Jiuwei Cui
Jun 10, 2020·Current Gene Therapy·Mahmoud GharbaviSaeed Ghanbarzadeh
Aug 28, 2019·ACS Applied Materials & Interfaces·Dan WuShuqi Wang
Aug 11, 2021·Molecules and Cells·Peter Karagiannis, Shin-Il Kim

❮ Previous
Next ❯

Related Concepts

Related Feeds

CREs: Gene & Cell Therapy

Gene and cell therapy advances have shown promising outcomes for several diseases. The role of cis-regulatory elements (CREs) is crucial in the design of gene therapy vectors. Here is the latest research on CREs in gene and cell therapy.

Allogenic & Autologous Therapies

Allogenic therapies are generated in large batches from unrelated donor tissues such as bone marrow. In contrast, autologous therapies are manufactures as a single lot from the patient being treated. Here is the latest research on allogenic and autologous therapies.

Cancer Vaccines

Cancer vaccines are vaccines that either treat existing cancer or prevent development of a cancer.

Cancer Biology: Molecular Imaging

Molecular imaging enables noninvasive imaging of key molecules that are crucial to tumor biology. Discover the latest research in molecular imaging in cancer biology in this feed.