Natural Killer Cell Characteristics in Patients With Chronic Hepatitis B Virus (HBV) Infection Are Associated With HBV Surface Antigen Clearance After Combination Treatment With Pegylated Interferon Alfa-2a and Adefovir

The Journal of Infectious Diseases
Femke StelmaEster M M van Leeuwen

Abstract

The role of natural killer (NK) cells in the process of hepatitis B virus (HBV) surface antigen (HBsAg) clearance and whether their phenotype is related to treatment outcome in patients with chronic hepatitis B are currently unknown. Patients with chronic hepatitis B (HBV DNA load, >17 000 IU/mL) were treated with pegylated interferon alfa-2a and adefovir for 48 weeks. NK cell phenotype and function were analyzed in 7 responders (defined as individuals with HBsAg clearance by week 72; 3 HBV e antigen [HBeAg]-positive and 4 HBeAg-negative), 7 matched nonresponders, and 7 healthy controls. Subsequently, 34 baseline samples from HBeAg-positive patients with chronic hepatitis B were analyzed. During treatment, the percentage and absolute number of CD56(bright) NK cells increased significantly, whereas the percentage and absolute number of CD56(dim) NK cells decreased. At baseline, responders had a significantly lower expression of chemokine receptor CX3CR1 on CD56(bright) NK cells and inhibitory receptor NKG2A on CD56(dim) NK cells, compared with nonresponders. In addition, responders had higher CD56(bright) TRAIL expression and interferon γ production at end of treatment. These baseline differences were not found in HBeAg-positive...Continue Reading

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Citations

Mar 30, 2016·Revista Española De Enfermedades Digestivas : Organo Oficial De La Sociedad Española De Patología Digestiva·Yun ZhangZhongfu Zhao
Apr 17, 2016·Journal of Hepatology·Mala K Maini, Adam J Gehring
Mar 16, 2017·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Femke StelmaHendrik W Reesink
Jul 22, 2016·Journal of Virology·Marianna Di ScalaGloria González-Aseguinolaza
May 28, 2019·Journal of Leukocyte Biology·Bingqing ZhengJian Zhang
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Aug 28, 2021·Journal of Clinical and Translational Hepatology·Yang LiYuxin Chen

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