Natural killer cell function predicts severe infection in kidney transplant recipients

American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons
Claire DendleStephen Holdsworth

Abstract

The aim of this study was to determine if natural killer cell number (CD3- /CD16± /CD56± ) and cytotoxic killing function predicts severity and frequency of infection in kidney transplant recipients. A cohort of 168 kidney transplant recipients with stable graft function underwent assessment of natural killer cell number and functional killing capacity immediately prior to entry into this prospective study. Participants were followed for 2 years for development of severe infection, defined as hospitalization for infection. Area under receiver operating characteristic (AUROC) curves were used to evaluate the accuracy of natural killer cell number and function for predicting severe infection. Adjusted odds ratios were determined by logistic regression. Fifty-nine kidney transplant recipients (35%) developed severe infection and 7 (4%) died. Natural killer cell function was a better predictor of severe infection than natural killer cell number: AUROC 0.84 and 0.75, respectively (P = .018). Logistic regression demonstrated that after adjustment for age, transplant function, transplant duration, mycophenolate use, and increasing natural killer function (odds ratio [OR] 0.82, 95% confidence interval [CI] 0.74-0.90; P < .0001) but not...Continue Reading

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Citations

Feb 23, 2020·Expert Review of Anti-infective Therapy·Mario Fernández-RuizJosé María Aguado
Aug 15, 2020·Frontiers in Immunology·Paola PontrelliGiovanni Stallone
Aug 18, 2020·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Matthew B Roberts, Jay A Fishman
Sep 4, 2021·Nanoscale Research Letters·Ying DuYanfei Shen

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