Natural killer cell receptor--repertoire and functions after induction therapy by polyclonal rabbit anti-thymocyte globulin in unsensitized kidney transplant recipients

Clinical Immunology : the Official Journal of the Clinical Immunology Society
K HadayaJean Villard

Abstract

Polyclonal rabbit anti-thymocyte globulin (rATG) is widely used in solid organ transplantation (SOT) as induction therapy or to treat corticosteroid-resistant rejection. In vivo, the effect of rATG on natural killer (NK) cells has not been studied. These cells are of particular relevance after SOT because classical immunosuppressive drugs do not inhibit or even can activate NK cells. A cohort of 20 recipients at low immunological risk, that had been receiving rATG as induction therapy, was analyzed for receptor repertoire, cytotoxicity and capacity of NK cells to secrete IFN-γ before kidney transplantation and at different time points thereafter. NK cells expressed fewer killer-cell immunoglobulin-like receptors (KIR), fewer activating receptors NKG2D, but more inhibitory receptor NKG2A compatible with an immature phenotype in the first 6 months post transplantation. Both cytotoxicity of NK cells and the secretion of IFN-γ were preserved over time after transplantation.

References

Jan 15, 2008·Transplantation·Lu-En WaiSheri M Krams
Oct 20, 2009·Trends in Immunology·Emmanuel ContassotBertrand Huard

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Citations

Mar 18, 2011·Journal of Innate Immunity·Jean Villard
Aug 1, 2011·Kidney International Supplements·Beatriz Suárez-ÁlvarezCarlos López-Larrea
Nov 11, 2016·Transplantation Direct·Astrid Tschan-PlesslGrzegorz Terszowski
Nov 1, 2016·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Jamal BamoulidKlemens Budde
May 1, 2021·Cancers·Cecilia Nakid-CorderoVincent Vieillard

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