Natural killer cells activated through NKG2D mediate lung ischemia-reperfusion injury.

The Journal of Clinical Investigation
Daniel R CalabreseJohn R Greenland

Abstract

Pulmonary ischemia-reperfusion injury (IRI) is a clinical syndrome of acute lung injury that occurs after lung transplantation or remote organ ischemia. IRI causes early mortality and has no effective therapies. While NK cells are innate lymphocytes capable of recognizing injured cells, their roles in acute lung injury are incompletely understood. Here, we demonstrated that NK cells were increased in frequency and cytotoxicity in 2 different IRI mouse models. We showed that NK cells trafficked to the lung tissue from peripheral reservoirs and were more mature within lung tissue. Acute lung ischemia-reperfusion injury was blunted in a NK cell-deficient mouse strain but restored with adoptive transfer of NK cells. Mechanistically, NK cell NKG2D receptor ligands were induced on lung endothelial and epithelial cells following IRI, and antibody-mediated NK cell depletion or NKG2D stress receptor blockade abrogated acute lung injury. In human lung tissue, NK cells were increased at sites of ischemia-reperfusion injury and activated NK cells were increased in prospectively collected human bronchoalveolar lavage in subjects with severe IRI. These data support a causal role for recipient peripheral NK cells in pulmonary IRI via NK cell ...Continue Reading

References

Jan 1, 1973·Annals of Surgery·S S SieglemanF J Veith
Aug 18, 2001·The Journal of Immunology : Official Journal of the American Association of Immunologists·C KarnbachM C Nakamura
Jan 9, 2004·Advances in Cancer Research·Jun Wu, Lewis L Lanier
Dec 18, 2004·Journal of Immunological Methods·Galit AlterMarcus Altfeld
Mar 15, 2005·American Journal of Respiratory and Critical Care Medicine·Jason D ChristieStephen E Kimmel
Dec 13, 2006·American Journal of Respiratory and Critical Care Medicine·Shiraz A DaudRamsey R Hachem
May 22, 2007·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·M OkazakiD Kreisel
Jul 16, 2008·American Journal of Physiology. Lung Cellular and Molecular Physiology·Gustavo Matute-BelloThomas R Martin
Aug 30, 2008·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·T OtoG I Snell
Oct 4, 2008·The Journal of Immunology : Official Journal of the American Association of Immunologists·Scott C WesselkamperMichael T Borchers
Nov 20, 2008·The Journal of Immunology : Official Journal of the American Association of Immunologists·Zhu-Xu ZhangAnthony M Jevnikar
Jan 6, 2009·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·S A HoffmanUNKNOWN Lung Transplant Outcomes Group
Feb 7, 2009·The Journal of Clinical Investigation·Michael T BorchersMauricio Orozco-Levi
Jun 12, 2010·Immunological Reviews·Marine Champsaur, Lewis L Lanier
Jun 15, 2010·The Journal of Immunology : Official Journal of the American Association of Immunologists·Jayne F MartinBibiana Bielekova
Sep 14, 2010·American Journal of Physiology. Heart and Circulatory Physiology·Willem A den HengstAn L Moens
Sep 28, 2010·The Annals of Thoracic Surgery·Ankit BharatThalachallour Mohanakumar
Jan 8, 2011·Science·Eric VivierSophie Ugolini
May 11, 2011·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Gang Eric ChenAlexandra Sharland
Sep 20, 2012·Translational Research : the Journal of Laboratory and Clinical Medicine·Rupal J ShahLorraine B Ware
Jan 10, 2013·Annual Review of Immunology·David H RauletHeiyoun Jung
Feb 12, 2014·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·J R GreenlandG H Caughey
Dec 9, 2014·American Journal of Respiratory and Critical Care Medicine·David M SayahMark R Looney
Oct 11, 2015·The Journal of Immunology : Official Journal of the American Association of Immunologists·Francisco VictorinoEric T Clambey
May 5, 2016·American Journal of Respiratory Cell and Molecular Biology·Ankit BharatThalachallour Mohanakumar
May 18, 2016·The Journal of Immunology : Official Journal of the American Association of Immunologists·Thomas VerrierChristian A J Vosshenrich
Oct 25, 2016·Autoimmunity Reviews·Christophe JaminJacques-Olivier Pers
Sep 8, 2016·Journal of Leukocyte Biology·Sandra HoeglEóin N McNamee
Apr 5, 2017·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·J R GreenlandR Rajalingam
Aug 3, 2017·International Journal of Molecular Sciences·Rosa MolfettaRossella Paolini
Aug 7, 2017·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Lars H LundUNKNOWN International Society for Heart and Lung Transplantation
Sep 21, 2017·International Journal of Molecular Sciences·Kasper Vadstrup, Flemming Bendtsen
Sep 26, 2017·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Gregory I SnellJason D Christie
Oct 11, 2017·Frontiers in Immunology·Alessandra ZingoniAlessandra Soriani
Feb 20, 2018·The Annals of Thoracic Surgery·Ankit Bharat, Daniel Kreisel
Apr 13, 2018·Bio-protocol·Roland Ruscher, Kristin A Hogquist
Aug 7, 2018·Frontiers in Immunology·Grace E CooperKarl J Staples
Nov 2, 2018·Thorax·Daniel R CalabreseJohn R Greenland
May 28, 2019·Frontiers in Immunology·Alexander David BarrowMarco Colonna
Aug 9, 2019·American Journal of Respiratory and Critical Care Medicine·Laurel A MonticelliJason D Christie
Oct 28, 2019·American Journal of Respiratory Cell and Molecular Biology·Beñat MallaviaMark R Looney

❮ Previous
Next ❯

Citations


❮ Previous
Next ❯

Methods Mentioned

BETA
flow cytometry
biopsy
biopsies
bronchoalveolar lavage
lavage

Software Mentioned

ggplot
stringr
Kaluza
mgcv
multcomp
ggpubr
Bioquant
STAT
R R Foundation for Statistical Computing
ordinal

Related Concepts

Related Feeds

Cancer Biology: Molecular Imaging

Molecular imaging enables noninvasive imaging of key molecules that are crucial to tumor biology. Discover the latest research in molecular imaging in cancer biology in this feed.

© 2021 Meta ULC. All rights reserved