Natural killer cells and their activation status in normal pregnancy

International Journal of Reproductive Medicine
Beatrice MosimannAmolak S Bansal

Abstract

Increased peripheral blood-activated NK cell counts are associated with increased risk of miscarriage and failed in vitro fertilization treatment. However, assessment of activated peripheral NK cells in normal and pathological pregnancies beyond implantation and early miscarriage has not been described. Total CD69 expressing NK cells counts were measured by flow cytometry in healthy women with singleton pregnancies, including 45 at 11(+6)-13(+6) weeks' gestation, 46 at 20(+0)-22(+4) weeks, and 42 at 31(+6)-33(+5) weeks. The number of peripheral blood NK cells decreased, whereas the percentage of activated CD69 expressing NK cells increased from the first to the third trimester of pregnancy. This study shows the course of peripheral blood NK cells and activated CD69 expressing NK cells in uncomplicated nulliparous singleton pregnancies. This is a first step in understanding their implication in pathological pregnancies.

References

Nov 1, 1983·American Journal of Obstetrics and Gynecology·P OzanneH J Meiselman
Feb 3, 1998·Journal of Immunological Methods·R CrastonM W Lowdell
Mar 3, 1998·European Journal of Obstetrics, Gynecology, and Reproductive Biology·M KühnertE Halberstadt
Aug 31, 1999·Immunopharmacology and Immunotoxicology·R MarzioS Betz-Corradin
Oct 19, 2000·The Journal of Biological Chemistry·A S LleraJ Tormo
Aug 15, 2001·Laboratory Investigation; a Journal of Technical Methods and Pathology·C HeligeG Dohr
Nov 8, 2001·Trends in Immunology·M A CooperM A Caligiuri
Dec 1, 2001·Gynecologic and Obstetric Investigation·F MahmoudK Whaley
Sep 5, 2002·Nature Reviews. Immunology·Ashley Moffett-King
Aug 5, 2003·Journal of Reproductive Immunology·I L SargentC W G Redman
Dec 21, 2004·Molecular Immunology·Judith N Bulmer, Gendie E Lash
Jul 18, 2006·Trends in Immunology·Ian L SargentChristopher W G Redman
Feb 6, 2007·European Journal of Obstetrics, Gynecology, and Reproductive Biology·Samuel LurieOscar Sadan
Dec 14, 2007·American Journal of Reproductive Immunology : AJRI·Marianne J van den HeuvelDavid A Clark
Jun 10, 2008·American Journal of Obstetrics and Gynecology·Amy H PicklesimerKim A Boggess
Oct 1, 2009·American Journal of Obstetrics and Gynecology·Simcha Yagel
Jan 13, 2010·American Journal of Reproductive Immunology : AJRI·Dong Wook ParkKwang Moon Yang
Mar 17, 2010·Journal of Reproductive Immunology·Marie TsampalasSophie Perrier d'Hauterive
Aug 26, 2010·Reproductive Biology and Endocrinology : RB&E·Laurence A Cole
Feb 8, 2011·Placenta·W NorrisS Kalkunte
Feb 22, 2011·Journal of Reproductive Immunology·Gendie E Lash, Judith N Bulmer
Jun 1, 2011·American Journal of Reproductive Immunology : AJRI·Edward E WingerMohamed Taranissi
Feb 3, 2012·American Journal of Reproductive Immunology : AJRI·Gavin SacksMichael Chapman
Mar 7, 2012·Immunologic Research·Marija MilovanovicMiodrag L Lukic
Jul 24, 2012·Journal of Reproductive Immunology·Jelmer R PrinsSarah A Robertson
Nov 22, 2012·Expert Review of Clinical Immunology·Amolak S BansalMeen-Yau Thum
Jan 15, 2013·American Journal of Reproductive Immunology : AJRI·Megumi YokotaHideki Mizunuma

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Citations

Jan 10, 2018·American Journal of Reproductive Immunology : AJRI·Thalita Frutuoso LoboSilvia Daher
Aug 23, 2019·Biology of Reproduction·Jennet BaltayevaAlexander G Beristain
Dec 15, 2020·American Journal of Reproductive Immunology : AJRI·Olivia K TravisDenise C Cornelius

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