Natural killer cells as a promising tool to tackle cancer-A review of sources, methodologies, and potentials

International Reviews of Immunology
Senthilkumar PreethySamuel J K Abraham

Abstract

Immune cell-based therapies are emerging as a promising tool to tackle malignancies, both solid tumors and selected hematological tumors. Vast experiences in literature have documented their safety and added survival benefits when such cell-based therapies are combined with the existing treatment options. Numerous methodologies of processing and in vitro expansion protocols of immune cells, such as the dendritic cells, natural killer (NK) cells, NKT cells, αβ T cells, so-called activated T lymphocytes, γδ T cells, cytotoxic T lymphocytes, and lymphokine-activated killer cells, have been reported for use in cell-based therapies. Among this handful of immune cells of significance, the NK cells stand apart from the rest for not only their direct cytotoxic ability against cancer cells but also their added advantage, which includes their capability of (i) action through both innate and adaptive immune mechanism, (ii) tackling viruses too, giving benefits in conditions where viral infections culminate in cancer, and (iii) destroying cancer stem cells, thereby preventing resistance to chemotherapy and radiotherapy. This review thoroughly analyses the sources of such NK cells, methods for expansion, and the future potentials of taking ...Continue Reading

References

Jun 1, 1978·The Journal of Experimental Medicine·M Jondal, S Targan
Jan 1, 1989·Pediatric Hematology and Oncology·R HandgretingerJ Treuner
Nov 11, 1993·International Journal of Cancer. Journal International Du Cancer·H F SewellR W Blamey
Jul 6, 2000·The Journal of Clinical Investigation·T A FehnigerM A Caligiuri
Nov 8, 2001·Trends in Immunology·M A CooperM A Caligiuri
Dec 31, 2003·Trends in Immunology·Megan A CooperMichael A Caligiuri
Jun 3, 2004·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Stefan W KrauseGabriele Multhoff
Jan 18, 2005·Current Opinion in Immunology·Jessica A HamermanLewis L Lanier
Apr 2, 2005·Nature Reviews. Cancer·Michael DeanSusan Bates
Apr 21, 2005·Nature Reviews. Immunology·Vinay Kumar, Megan E McNerney
Jun 3, 2006·Seminars in Immunology·David H Raulet
Dec 13, 2006·Archives of Ophthalmology·Ivan R SchwabDamien G Harkin
Feb 20, 2007·Molecular Cancer Therapeutics·Laszlo MarkaszLaszlo Szekely
Mar 21, 2007·The Journal of Immunology : Official Journal of the American Association of Immunologists·Loris ZamaiMarco Vitale
Apr 22, 2008·Nature Immunology·Eric VivierSophie Ugolini
Mar 10, 2009·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Md Zahidunnabi DewanMasakazu Toi
Mar 13, 2009·Immunology·Aurélie PoliJacques Zimmer
Apr 23, 2009·Cancer Research·Hiroyuki FujisakiDario Campana
Aug 20, 2009·Immunology·Nicola J Topham, Eric W Hewitt
Apr 1, 2010·Breast Cancer : the Journal of the Japanese Breast Cancer Society·Masahiro TakadaMasakazu Toi
Jan 1, 2008·Expert Review of Clinical Immunology·Suraksha AgrawalSita Naik

❮ Previous
Next ❯

Citations

Apr 15, 2021·Journal of Biological Engineering·Oscar Fabian Garcia-AponteBence Kozma

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cancer Vaccines

Cancer vaccines are vaccines that either treat existing cancer or prevent development of a cancer.

Antivirals (ASM)

Antivirals are medications that are used specifically for treating viral infections. Discover the latest research on antivirals here.

Cancer Biology: Molecular Imaging

Molecular imaging enables noninvasive imaging of key molecules that are crucial to tumor biology. Discover the latest research in molecular imaging in cancer biology in this feed.

CREs: Gene & Cell Therapy

Gene and cell therapy advances have shown promising outcomes for several diseases. The role of cis-regulatory elements (CREs) is crucial in the design of gene therapy vectors. Here is the latest research on CREs in gene and cell therapy.

Allogenic & Autologous Therapies

Allogenic therapies are generated in large batches from unrelated donor tissues such as bone marrow. In contrast, autologous therapies are manufactures as a single lot from the patient being treated. Here is the latest research on allogenic and autologous therapies.

Antivirals

Antivirals are medications that are used specifically for treating viral infections. Discover the latest research on antivirals here.