Natural killer cells as a therapeutic tool for infectious diseases - current status and future perspectives

Oncotarget
Stanislaw SchmidtThomas Lehrnbecher

Abstract

Natural Killer (NK) cells are involved in the host immune response against infections due to viral, bacterial and fungal pathogens, all of which are a significant cause of morbidity and mortality in immunocompromised patients. Since the recovery of the immune system has a major impact on the outcome of an infectious complication, there is major interest in strengthening the host response in immunocompromised patients, either by using cytokines or growth factors or by adoptive cellular therapies transfusing immune cells such as granulocytes or pathogen-specific T-cells. To date, relatively little is known about the potential of adoptively transferring NK cells in immunocompromised patients with infectious complications, although the anti-cancer property of NK cells is already being investigated in the clinical setting. This review will focus on the antimicrobial properties of NK cells and the current standing and future perspectives of generating and using NK cells as immunotherapy in patients with infectious complications, an approach which is promising and might have an important clinical impact in the future.

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Citations

Oct 17, 2019·Cancers·Sooyeon OhSang-Woon Choi
Nov 21, 2018·Antimicrobial Agents and Chemotherapy·Stanislaw SchmidtThomas Lehrnbecher
Jan 29, 2019·Frontiers in Microbiology·Andrzej GórskiBeata Weber-Dąbrowska
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Jan 13, 2021·Cytotherapy·Soumyadipta KunduMichael O'Dwyer
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Mar 7, 2021·Journal of Fungi·Stanislaw SchmidtThomas Lehrnbecher
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Methods Mentioned

BETA
in
genetic modification

Clinical Trials Mentioned

NCT01619761
NCT01729091
NCT00995137
NCT01974479

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