PMID: 16507413Mar 2, 2006Paper

Natural killer cells in breast cancer cell growth and metastasis in SCID mice

Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie
Md Zahidunnabi DewanNaoki Yamamoto

Abstract

Natural killer (NK) cell is an important component of the innate immune system and plays a central role in host defense against tumor and virus-infected cells. This review briefly summarizes the role of murine NK cells in tumor growth and metastasis of breast cancer cells in severe combined immunodeficiency (SCID) mice. Conventional SCID and NOD-SCID strains have been used to study for xenotransplantion of human tumors. SCID mice models of cancer mimic human diseases and have provided valuable information. However, these mice strains have some residual immunity such as NK cells that somewhat limit post-transplantation growth and metastasis of human xenografts. In contrast, NOD/SCID/gammac(null) (NOG) mice without common gamma-chain inoculated with breast cancer cells were most efficient in the formation of a large tumor and metastasis. NOG mouse strain without NK activity appears to be more promising as tool for xenotransplantion of human cancer. This new xenotransplant model is relevant and can be recommended for use in clarifying the mechanism of growth of cancer cells as well as for developing new therapeutic strategies against cancer.

References

Dec 15, 1979·International Journal of Cancer. Journal International Du Cancer·F E Sharkey, J Fogh
Feb 15, 1976·International Journal of Cancer. Journal International Du Cancer·B Armstrong
Oct 1, 1991·Cancer Metastasis Reviews·T M SweeneyH K Kleinman
Mar 12, 1991·International Journal of Cancer. Journal International Du Cancer·A L ZietmanH D Suit
Jul 15, 1991·Proceedings of the National Academy of Sciences of the United States of America·W J StorkusJ R Dawson
Jan 1, 1985·The Journal of Experimental Medicine·J F BukowskiR M Welsh
Dec 1, 1987·Breast Cancer Research and Treatment·N BrünnerM Spang-Thomsen
Jun 1, 1974·The British Journal of Surgery·J E Castro, W Cass
Feb 10, 1983·Nature·G C BosmaM J Bosma
Feb 15, 1982·International Journal of Cancer. Journal International Du Cancer·S B Pollack, L A Hallenbeck
Oct 15, 1994·International Journal of Cancer. Journal International Du Cancer·L AdamL Israel
Jan 1, 1996·Breast Cancer Research and Treatment·J E Price
Nov 6, 1996·Journal of the National Cancer Institute·K C ChuB K Edwards
May 5, 2001·Immunity·R LechlerR M Steinman
Apr 25, 2003·International Journal of Cancer. Journal International Du Cancer·Philipp BeckhoveVolker Schirrmacher

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Citations

Jun 25, 2013·Human Immunology·Maria Regina JobimGilberto Schwartsmann
Aug 16, 2011·The Journal of Clinical Investigation·Emilie MamessierDaniel Olive
May 1, 2009·Immunotherapy·Lisbeth Barkholt, Marco Bregni
Nov 21, 2012·Regenerative Medicine·Erik R BarthelTracy C Grikscheit
May 26, 2009·Clinical & Experimental Metastasis·Sylvia E Le DévédecBob van de Water
Oct 18, 2012·Molecular and Cellular Neurosciences·Alastair Hamilton, Nicola R Sibson
Jun 28, 2012·Oncoimmunology·Emilie MamessierDaniel Olive
Jun 25, 2013·Molecular and Cellular Endocrinology·Xinguo Jiang, David J Shapiro
Jun 20, 2008·Proceedings of the National Academy of Sciences of the United States of America·Dipak K SarkarJason Marano
Sep 24, 2016·PloS One·Madhavi PuchalapalliJennifer E Koblinski
Nov 9, 2019·Journal of Clinical Medicine·Maria Felicia FiordelisiMarco Salvatore
Jun 9, 2017·Current Opinion in Hematology·Marco Pizzi, Giorgio Inghirami
Sep 29, 2019·International Journal of Molecular Sciences·Ivan RanđelovićJózsef Tóvári
Dec 11, 2019·Pathology Oncology Research : POR·Andrea Angelo Pierluigi TripodiJózsef Tóvári
May 26, 2017·Hematological Oncology·Peter W Kyriakides, Giorgio Inghirami
Dec 28, 2016·Cancer Metastasis Reviews·Lacey E DobroleckiMichael T Lewis
Mar 25, 2021·Journal of Experimental & Clinical Cancer Research : CR·Mitsuhito HiranoArinobu Tojo
Aug 14, 2021·Advanced Drug Delivery Reviews·Victoria LaiJoshua C Doloff

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